CAJ | 학술논문

目的评价吸入异丙托溴胺(ipratropium bromide,IPB)是否改善慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者的静态肺功能,运动通气功能和运动耐量.方法随机抽取稳定期COPD患者12例,吸入IPB溶液2 mg,吸人前后分别进行静态肺功能和运动肺功能测定.结果吸入IPB后,COPD患者最大运动功率(Wmax)、最大耗氧量(VO2max)、最大运动时每分钟通气量(Vemax)和比潮气量(Vtmax/IC),较吸人前均有显著增加;死腔通气(VD/VT)和二氧化碳通气当量(Vemax/VCO2max)无明显改变.Vtmax/IC的变化(⊿Vtmax/IC)与VO2max的变化(⊿VO2max)有显著相关性(r=0.598,P＜0.05);⊿Vtmax/IC与最大运动功率的变化(⊿Wmax)也存在显著相关性(r=0.743,P＜0.05).结论吸入IPB能够增加COPD患者的运动耐量,COPD患者吸入IPB后,⊿Vtmax/IC可能是运动耐量增加机制中的一个重要环节.
목적 평개흡입이병탁추알(ipratropium bromide,IPB)시부개선만성조새성폐질병(chronic obstructive pulmonary disease,COPD)환자적정태폐공능,운동통기공능화운동내량.방법 수궤추취은정기COPD환자12례,흡입IPB용액2 mg,흡인전후분별진행정태폐공능화운동폐공능측정.결과 흡입IPB후,COPD환자최대운동공솔(Wmax)、최대모양량(VO2max)、최대운동시매분종통기량(Vemax)화비조기량(Vtmax/IC),교흡인전균유현저증가;사강통기(VD/VT)화이양화탄통기당량(Vemax/VCO2max)무명현개변.Vtmax/IC적변화(⊿Vtmax/IC)여VO2max적변화(⊿VO2max)유현저상관성(r=0.598,P＜0.05);⊿Vtmax/IC여최대운동공솔적변화(⊿Wmax)야존재현저상관성(r=0.743,P＜0.05).결론 흡입IPB능구증가COPD환자적운동내량,COPD환자흡입IPB후,⊿Vtmax/IC가능시운동내량증가궤제중적일개중요배절.
Objective To evaluate the effect of inhaling ipratropium bromide(IPB)to patients with chronic obstructive pulmonary disease(COPD)on ventilation and exercise capacity during exercise.Methods All 12 stable patients were diagnosed as COPD.Before and after inhaling single-dose IPB,symptom-limited progressive cycle ergometer exercise tests were performed.Results The maximal rate of work,maximal oxygen uptake,the maximal volume of ventilation per minute and the maximal ratio of tidal volume to inspiratory capacity increased significantly after inhaling IPB solution of four times the standard dose.The maximal dead space/tidal volume ratio and the maximal ventilatory equivalent for CO2 had no change.There was a significant correlation between the amount of the maximal ratio of tidal volume to inspiratory capacity improved and amount of maximal oxygen uptake improved(r=0.598,P＜0.05).Another significant correlation exited between the amount of maximal rate of work improved and amount of the maximal ratio of tidal volume to inspiratory capacity improved(r=0.743,P＜0.05).Conclusions Inhaling single-dose IPB will be helpful in improving exercise tolerance of patients.The improvement of maximal ratio of tidal volume to inspiratory capacity could be an important factor about inhaling IPB how to improve exercise tolerance of patients.