中华传染病杂志
中華傳染病雜誌
중화전염병잡지
CHINESE JOURNAL OF INFECTIOUS DISEASES
2009年
4期
225-227
,共3页
彭劼%侯金林%郭亚兵%冯筱榕%朱幼芙
彭劼%侯金林%郭亞兵%馮篠榕%硃幼芙
팽할%후금림%곽아병%풍소용%주유부
肝炎,乙型,慢性%肝炎e抗原,乙型%DNA,病毒%预后
肝炎,乙型,慢性%肝炎e抗原,乙型%DNA,病毒%預後
간염,을형,만성%간염e항원,을형%DNA,병독%예후
Hepatitis B,chronic%Hepatitis B e antigens%DNA,viral%Prognosis
目的 探讨HBeAg状态及HBV DNA载量对慢性重型乙型肝炎预后的影响.方法 回顾分析2002年1月至2007年12月在南方医科大学南方医院住院的慢性重型乙型肝炎患者406例,研究HBeAg状态、HBV DNA载量对疾病预后的影响.计量资料采用t检验,率的比较采用X2检验.结果 406例重型肝炎患者中,HBeAg阳性208例,占51.2%,HBeAg阴性198例,占48.8%.HBeAg阳性组与HBeAg阴性组比较,两组间男女构成比、TBil峰值及平均凝血酶原活动度谷值差异均无统计学意义;HBeAg阴性组平均年龄(46.7±12.8)岁,显著高于HBeAg阳性组(38.3±13.5)岁(t=6.43,P＜0.01);HBeAg阴性组肝硬化患者占67.7%,亦显著高于HBeAg阳性组的45.7%(X2=19.97,P＜0.01);HBeAg阴性组好转率为32.3%,显著低于HBeAg阳性组的44.7%(X2=6.56,P＜0.05).在208例HBeAg阳性与198例HBeAg阴性患者中,均显示随着HBV DNA载量的升高,其好转率下降,呈显著负相关(X2=22.98,X2=26.04;均P＜0.01).结论 HBeAg阴性重型乙型肝炎较HBeAg阳性者预后差;无论HBeAg状态如何,HBV DNA载量越高,其预后越差.
目的 探討HBeAg狀態及HBV DNA載量對慢性重型乙型肝炎預後的影響.方法 迴顧分析2002年1月至2007年12月在南方醫科大學南方醫院住院的慢性重型乙型肝炎患者406例,研究HBeAg狀態、HBV DNA載量對疾病預後的影響.計量資料採用t檢驗,率的比較採用X2檢驗.結果 406例重型肝炎患者中,HBeAg暘性208例,佔51.2%,HBeAg陰性198例,佔48.8%.HBeAg暘性組與HBeAg陰性組比較,兩組間男女構成比、TBil峰值及平均凝血酶原活動度穀值差異均無統計學意義;HBeAg陰性組平均年齡(46.7±12.8)歲,顯著高于HBeAg暘性組(38.3±13.5)歲(t=6.43,P＜0.01);HBeAg陰性組肝硬化患者佔67.7%,亦顯著高于HBeAg暘性組的45.7%(X2=19.97,P＜0.01);HBeAg陰性組好轉率為32.3%,顯著低于HBeAg暘性組的44.7%(X2=6.56,P＜0.05).在208例HBeAg暘性與198例HBeAg陰性患者中,均顯示隨著HBV DNA載量的升高,其好轉率下降,呈顯著負相關(X2=22.98,X2=26.04;均P＜0.01).結論 HBeAg陰性重型乙型肝炎較HBeAg暘性者預後差;無論HBeAg狀態如何,HBV DNA載量越高,其預後越差.
목적 탐토HBeAg상태급HBV DNA재량대만성중형을형간염예후적영향.방법 회고분석2002년1월지2007년12월재남방의과대학남방의원주원적만성중형을형간염환자406례,연구HBeAg상태、HBV DNA재량대질병예후적영향.계량자료채용t검험,솔적비교채용X2검험.결과 406례중형간염환자중,HBeAg양성208례,점51.2%,HBeAg음성198례,점48.8%.HBeAg양성조여HBeAg음성조비교,량조간남녀구성비、TBil봉치급평균응혈매원활동도곡치차이균무통계학의의;HBeAg음성조평균년령(46.7±12.8)세,현저고우HBeAg양성조(38.3±13.5)세(t=6.43,P＜0.01);HBeAg음성조간경화환자점67.7%,역현저고우HBeAg양성조적45.7%(X2=19.97,P＜0.01);HBeAg음성조호전솔위32.3%,현저저우HBeAg양성조적44.7%(X2=6.56,P＜0.05).재208례HBeAg양성여198례HBeAg음성환자중,균현시수착HBV DNA재량적승고,기호전솔하강,정현저부상관(X2=22.98,X2=26.04;균P＜0.01).결론 HBeAg음성중형을형간염교HBeAg양성자예후차;무론HBeAg상태여하,HBV DNA재량월고,기예후월차.
Objective To evaluate the impact of hepatitis B e antigen (HBeAg) states and hepatitis B virus DNA loads on the prognosis of chronic severe hepatitis B.Methods A total of 406 hospitalized patients with chronic severe hepatitis B in Nanfang Hospital of Southern Medical University from January 2002 to December 2007 were retrospectively analyzed.The impact of HBeAg states and HBV DNA loads on the prognosis was evaluated.The measurement data were compared by t test and rates were compared by chi square test.Results Of all the 406 patients with chronic severe hepatitis B,208 (51.2%) patients were HBeAg-positive and the remaining 198 (48.8%) were HBeAgnegative.There was no significant difference of constituent ratio of male and female,average peak value of total bilirubin and average valley value of prothrombin activity between HBeAg-positive group and HBeAgnegative group.However,the average age of HBeAg-negative patients was (46.7±12.8) years old,which was significantly higher than that (38.3±13.5) years old in HBeAg-positive group (t = 6.43,P＜0.01 )the proportion of patients with liver cirrhosis in HBeAg-negative group (67.7%) was much higher than that in HBeAg-positive group (45.7%) (X2=19.97,P＜0.01);the improved rate in HBeAg-negative group (32.3%) was significant lower than that in HBcAg-positive group (44.7%) (X2=6.56,P＜0.05).Increasing HBV DNA levels was associated with lower improved rate in both 208 HBeAg-positive and 198 HBeAg-negative patients(X2=22.98,26.04,respectively,both P＜0.01 ).Conclusions HBeAg-negative patients with chronic severe hepatitis B has worse prognosis than HBeAg-positive patients;and the prognosis is getting worse with the increasing HBV DNA level regardless of the HBeAg status.
