CAJ | 학술논문

目的运用正葡萄糖高胰岛素钳夹技术评价多囊卵巢综合征(PCOS)患者白细胞介素18(IL-18)血清浓度和胰岛素抵抗的关系.方法共收集42例PCOS患者和38例年龄和体重指数(BMI)相匹配的对照组女性的相关临床资料,并检测其血清IL-18浓度.对其中41例受试者进行正葡萄糖高胰岛素钳夹试验.计算胰岛素抵抗各相关指标[稳态期平均葡萄糖输注率(M),单位血清胰岛素浓度下葡萄糖输注率(M/I)及葡萄糖代谢清除率(MCRg)值].结果 PCOS患者血清IL-18水平显著高于对照组(P=0.033).而肥胖组与正常体重组相比,IL-18血清浓度并无显著差异(P=0.902).血清IL-18浓度与钳夹试验所得各参数呈显著负相关(与M、M/I和MCRg分别为r=-0.419、-0.396和-0.405,分别P=0.006、0.010和0.009),而与稳态模型评估β细胞功能指数(HOMA-β)指数间呈显著的正相关(r=0.334,P=0.035).结论血清IL-18浓度在PCOS患者中显著升高,同时其值与钳夹试验所得反映胰岛素抵抗的各参数间显著负相关,提示IL-18血清浓度可能是介导体内炎症过程与胰岛素抵抗发生间的重要细胞因子.
목적 운용정포도당고이도소겸협기술평개다낭란소종합정(PCOS)환자백세포개소18(IL-18)혈청농도화이도소저항적관계.방법 공수집42례PCOS환자화38례년령화체중지수(BMI)상필배적대조조녀성적상관림상자료,병검측기혈청IL-18농도.대기중41례수시자진행정포도당고이도소겸협시험.계산이도소저항각상관지표[은태기평균포도당수주솔(M),단위혈청이도소농도하포도당수주솔(M/I)급포도당대사청제솔(MCRg)치].결과 PCOS환자혈청IL-18수평현저고우대조조(P=0.033).이비반조여정상체중조상비,IL-18혈청농도병무현저차이(P=0.902).혈청IL-18농도여겸협시험소득각삼수정현저부상관(여M、M/I화MCRg분별위r=-0.419、-0.396화-0.405,분별P=0.006、0.010화0.009),이여은태모형평고β세포공능지수(HOMA-β)지수간정현저적정상관(r=0.334,P=0.035).결론 혈청IL-18농도재PCOS환자중현저승고,동시기치여겸협시험소득반영이도소저항적각삼수간현저부상관,제시IL-18혈청농도가능시개도체내염증과정여이도소저항발생간적중요세포인자.
Objective To evaluate the relationship between interleukin-18(IL-18) and insulin resistance, measured by euglycemic hyperinsulinemic clamp, in women with polycystic ovary syndrome (PCOS). Methods Forty-two young women with PCOS and 38 age-and body mass index (BMI)- matched control women were recruited in this study. A complete hormonal assay was performed and serum IL-18 level was determined in each subject. And euglycemic hyperinsulinemic clamp test was completed in 41 of the above subjects. Results Serum IL-18 levels were increased in the PCOS women, as compared with the control (P=0.033). When all subjects were divided into lean and obese groups, the IL-18 levels were slightly increased in the obese subjects (P=0.902). IL-18 levels were negatively correlated with all the clamp parameters [mean glucose infusion rate (M), M-to-insulin ratio (M/I) and glucose metabolic clearance rate (MCRg), r =-0.419,-0.396,and-0.405,P=0.006,0.010 and 0.009 respectively], but were positively associated with HOMA-β index(r=0.334, P=O.035). Conclusion Serum IL-18 level was significantly increased in PCOS women and was strongly associated with the parameters obtained from the euglycemic hyperinsulinemic clamp, indicating that IL-18 may be an important mediator between inflammation and insulin resistance.