CAJ | 학술논문

基因间长链非编码RNA(large intergenic non-coding RNA,lincRNA)是由蛋白编码基因间的非编码序列转录且转录本长度超过200个核苷酸的功能性RNA分子.至今在哺乳动物基因组中已发现3500多种lincRNAs,它们通过调控基因的表达参与机体的生理过程,而且在实体瘤和白血病中发现很多lincRNAs存在异常表达.该文就lincRNA的功能研究进展及lincRNA在肿瘤发生发展中的作用作一综述.
기인간장련비편마RNA(large intergenic non-coding RNA,lincRNA)시유단백편마기인간적비편마서렬전록차전록본장도초과200개핵감산적공능성RNA분자.지금재포유동물기인조중이발현3500다충lincRNAs,타문통과조공기인적표체삼여궤체적생리과정,이차재실체류화백혈병중발현흔다lincRNAs존재이상표체.해문취lincRNA적공능연구진전급lincRNA재종류발생발전중적작용작일종술.
Large intergenic non-coding RNAs(lincRNAs) are functional RNA molecules whose transcripts are more than 200 nt.And these transcripts of lincRNAs are non-coding sequences just located between the protein-coding genes.More than 3500 lincRNAs have been reported in mammalian genome so far,which involved in body ' s physiological processes through the regulation of gene expression.What ' s more,it is also found that the aberrant expression of lincRNAs existed in both solid tumor and leukemia.Therefore we summarized the latest research progress about the function of lincRNAs and how lincRNAs work in the tumor development.