CAJ | 학술논문

目的探讨老年女性糖尿病患者尿路感染病原菌的分布情况及耐药特征,为临床合理使用抗菌素提供依据.方法收集老年女性糖尿病患者尿路感染病原菌107株,采用法国梅里埃公司VITEK32分析仪进行细菌鉴定和体外药敏试验.结果 107株病原菌中,革兰阴性杆菌感染占74.8%(80/107),以大肠埃希菌为主,占48.6(52/107);革兰阳性球菌占13.1%(14/107);真菌占12.1%(13/107).革兰阴性杆菌对氨苄西林、头孢唑啉、头孢呋辛钠、头孢呋辛酯耐药率均高于70.0%,对亚胺培南、丁胺卡那霉素耐药率均低于10.0%.革兰阳性球菌对万古霉素、利奈唑烷耐药率分别为0和7.1%(1/14).结论老年女性糖尿病患者尿路感染主要病原菌是大肠埃希菌,该菌耐药性较强,临床上应加强糖尿病患者尿路感染病原菌的检测和耐药性监测.
목적 탐토노년녀성당뇨병환자뇨로감염병원균적분포정황급내약특정,위림상합리사용항균소제공의거.방법 수집노년녀성당뇨병환자뇨로감염병원균107주,채용법국매리애공사VITEK32분석의진행세균감정화체외약민시험.결과 107주병원균중,혁란음성간균감염점74.8%(80/107),이대장애희균위주,점48.6(52/107);혁란양성구균점13.1%(14/107);진균점12.1%(13/107).혁란음성간균대안변서림、두포서람、두포부신납、두포부신지내약솔균고우70.0%,대아알배남、정알잡나매소내약솔균저우10.0%.혁란양성구균대만고매소、리내서완내약솔분별위0화7.1%(1/14).결론 노년녀성당뇨병환자뇨로감염주요병원균시대장애희균,해균내약성교강,림상상응가강당뇨병환자뇨로감염병원균적검측화내약성감측.
Objective To determine the distribution and antibiotics resistance characteristic of pathogens in urinary tract infections in aged female diabetics patients and provide scientific basis for clinicians in selecting effective antibiotics. Methods Pathogenic bacteria, isolated from specimens of 107 elderly female diabetic cases with urinary tract infections, were identified and drug susceptibility tests were performed by VITEK-32 analysator. Results Among all 107 kinds of isolated bacteria,the ratio of gram-negative bacteria was 74. 8% ( 80/107 ), predominated by Escherichiacoli ( accounting for 48. 6% [52/107] ); the ratio of gramposition bacterias was 13. 1% (14/107) and eumycetes was 12. 1% (13/107). In antibiotic resistance analysis,the gram negative bacteria showed higher drug-resistance to the some common-antibiotics, such as ampicililin,cefazolin,cefuroxime-sodium and cefuroxime axetil ( ＞ 70. 0% ), while they were sensitive to imipenem and amikacin( ＜ 10. 0% ). The gram positive bacteria were most sensitive to vancomycin (0%), followed by Linezolid(7.7% ). Conclusion Escherichiacoli were the major pathogenic bacteria in urinary tract infections in aged female diabetic patients, with higher drug resistance. Therefore, drug resistance monitoring should be carried out according to the variety of pathogenic bacteria so as to guide rational use of antibiotics and decrease drug resistance.