中国医药
中國醫藥
중국의약
CHINA MEDICINE
2010年
3期
236-238
,共3页
肺结核%抗结核药%硫酸卷曲霉素%药物疗法
肺結覈%抗結覈藥%硫痠捲麯黴素%藥物療法
폐결핵%항결핵약%류산권곡매소%약물요법
Pulmonary tuberculosis%Antitubercular agents%Capreomucin sulfate%Drug therapy
目的 评价硫酸卷曲霉素(CPM)超声雾化吸入联合抗结核药物治疗复治抗酸杆菌阳性(菌阳)肺结核的疗效.方法 126例复治菌阳肺结核患者以随机数字表法分为治疗组和对照组,2组均以合理抗结核化疗方案,治疗组加用硫酸卷曲霉素0.75g/次,1次/d超声雾化吸入治疗.观察2组治疗前后细菌学检查及胸部影响学检查资料的变化.结果 经过3个月的治疗,治疗组的痰菌阴转率为82.5%(52例),肺部病变吸收总有效率为93.6%(59例),空洞闭合或缩小的总有效率为93.6%(59例);对照组的痰菌阴转率为61.9%(39例),肺部病变吸收总有效率为73.0%(46例),空洞闭合或缩小的总有效率为80.9%(51例);治疗组明显优于对照组,差异有统计学意义(P<0.01).结论 并用卷曲霉素超声雾化吸入治疗复治菌阳肺结核疗效优于对照组,远期疗效需进一步研究.
目的 評價硫痠捲麯黴素(CPM)超聲霧化吸入聯閤抗結覈藥物治療複治抗痠桿菌暘性(菌暘)肺結覈的療效.方法 126例複治菌暘肺結覈患者以隨機數字錶法分為治療組和對照組,2組均以閤理抗結覈化療方案,治療組加用硫痠捲麯黴素0.75g/次,1次/d超聲霧化吸入治療.觀察2組治療前後細菌學檢查及胸部影響學檢查資料的變化.結果 經過3箇月的治療,治療組的痰菌陰轉率為82.5%(52例),肺部病變吸收總有效率為93.6%(59例),空洞閉閤或縮小的總有效率為93.6%(59例);對照組的痰菌陰轉率為61.9%(39例),肺部病變吸收總有效率為73.0%(46例),空洞閉閤或縮小的總有效率為80.9%(51例);治療組明顯優于對照組,差異有統計學意義(P<0.01).結論 併用捲麯黴素超聲霧化吸入治療複治菌暘肺結覈療效優于對照組,遠期療效需進一步研究.
목적 평개류산권곡매소(CPM)초성무화흡입연합항결핵약물치료복치항산간균양성(균양)폐결핵적료효.방법 126례복치균양폐결핵환자이수궤수자표법분위치료조화대조조,2조균이합리항결핵화료방안,치료조가용류산권곡매소0.75g/차,1차/d초성무화흡입치료.관찰2조치료전후세균학검사급흉부영향학검사자료적변화.결과 경과3개월적치료,치료조적담균음전솔위82.5%(52례),폐부병변흡수총유효솔위93.6%(59례),공동폐합혹축소적총유효솔위93.6%(59례);대조조적담균음전솔위61.9%(39례),폐부병변흡수총유효솔위73.0%(46례),공동폐합혹축소적총유효솔위80.9%(51례);치료조명현우우대조조,차이유통계학의의(P<0.01).결론 병용권곡매소초성무화흡입치료복치균양폐결핵료효우우대조조,원기료효수진일보연구.
Objectives To evaluate the therapeutic effect of capreomucin (CPM)ultrasonic aerosol inhala-tion spray combined with antitubercular agents in the treatment of retreated sputum positive pumonary tuberculosis.Methods One hundred and twenty-six retreated patients with sputum positive of AFB were randomly divided into 2 groups: treatment group had CPM aerosolization combined with rational chemotherapy and control group only had chemotherapy. Results After 3 months of treatment, the rates of sputum negtive conversion and radiological im-provement in the treatment group were 82.5% and 93.7% respectively, much higher than those in the control group (73.0% and 80.9% respectively) (P< 0.01). Conclusion Our study showes that antitubercular agents with CPM ultrasonic aerosolization have better therapeutic effect than chemotherapy alone.
