CAJ | 학술논문

根据胰岛自身抗体(A)阳性与否和是否保留有胰岛功能(B),将105例酮症起病的糖尿病患者分A+B-、A+B+、A-B-、A-B+4个组,观察对胰岛素依赖性.A-B+组非胰岛素依赖占94％ (46/49),A-B-组占1/10,而A+B-组为20％( 4/20)、A+B+组为58％ (15/26)；A-B+组IL-6水平最低,而肿瘤坏死因子α水平最高,IL-18水平则A+B-和A+B+组较高.提示酮症起病的糖尿病患者临床特点存在差异,自身免疫抗体和胰岛β细胞功能可提示临床表型亚型的归类,从而采取不同的治疗策略.
근거이도자신항체(A)양성여부화시부보류유이도공능(B),장105례동증기병적당뇨병환자분A+B-、A+B+、A-B-、A-B+4개조,관찰대이도소의뢰성.A-B+조비이도소의뢰점94％ (46/49),A-B-조점1/10,이A+B-조위20％( 4/20)、A+B+조위58％ (15/26)；A-B+조IL-6수평최저,이종류배사인자α수평최고,IL-18수평칙A+B-화A+B+조교고.제시동증기병적당뇨병환자림상특점존재차이,자신면역항체화이도β세포공능가제시림상표형아형적귀류,종이채취불동적치료책략.
A total of 105 patients with ketosis-onset diabetes were divided into four groups (A+B-,A + B +,A - B -,A - B +) based on the results of islet-associated autoantibodies (A +,A - ) and β-cell function (B +,B - ).Nearly 94％ patients in the A -B + group and 1/10 patients in the A - B - group were non-insulin dependent.While in the A + B - and A + B + groups,the detection rates of subsequent non-insulin dependency were 20％ and 58％,respectively.Among the four groups,patients in the A - B + groups had a lower level of IL-6 and a higher level of TNF-α. Patients in the A + B - and A + B + groups had a higher level of IL-18.Our study indicates that patients with ketosis-onset diabetes may present different clinical characteristics. Evaluate the islet-associated autoantibodies and pancreatic β-cell function may be helpful to the clinical diagnostic and therapeutic strategies in diabetes.