CAJ | 학술논문

目的：探讨放射免疫显像(radioimmunoimaging，RII)在食管癌转移淋巴结定位的临床应用。方法：1.131I标记抗人食管鳞癌单抗G9，形成标记化合物，在胸段食管鳞癌的术前病例，于纤维食管镜下，用纤镜专用注射针，在食管原发灶周围，粘膜下注射131I-G9后行RII。2.完成RII后，对清扫淋巴结行放射性测定。结果：1.注药48h时RII在食管旁纵隔、贲门旁、胃小弯旁出现散在的细点状放射性浓集，拟为转移淋巴结所在。2.显像出现散在放射性浓集区域所清扫的淋巴结中，包含有转移淋巴结；无浓集区域，未发现转移淋巴结。3.全部有转移淋巴结的放射性比活度(cpm/g)均比无转移者高，且均数高出两倍多。结论：用131I-G9在食管鳞癌行放射免疫显像，对转移淋巴结有定位作用。
목적：탐토방사면역현상(radioimmunoimaging，RII)재식관암전이림파결정위적림상응용。방법：1.131I표기항인식관린암단항G9，형성표기화합물，재흉단식관린암적술전병례，우섬유식관경하，용섬경전용주사침，재식관원발조주위，점막하주사131I-G9후행RII。2.완성RII후，대청소림파결행방사성측정。결과：1.주약48h시RII재식관방종격、분문방、위소만방출현산재적세점상방사성농집，의위전이림파결소재。2.현상출현산재방사성농집구역소청소적림파결중，포함유전이림파결；무농집구역，미발현전이림파결。3.전부유전이림파결적방사성비활도(cpm/g)균비무전이자고，차균수고출량배다。결론：용131I-G9재식관린암행방사면역현상，대전이림파결유정위작용。
Objective: The current study was designed to evaluate the clinical application of radioimmunoimaging(RII) for lymph node metastasis in esophageal carcinoma. Methods:1)131I was used to label McAb G9(specific to cellular membrane antigen of human esophageal carcinoma) and form labeling compound 131I-G9. Administration of 131I-G9 in esophagus submucosally with a specific injector for the purpose of submucosal injection via endoscopies in preoperative patients with squamous cell carcinoma of thoracic esophagus followed by RII. 2)The samples of dissected lymph node were used for detection of radioactivity. Results: 1)The pictures at 48 h showed that small radioactivity concentrated dots appeared dispersedly in mediastinum and upper abdomen around esophagus and cardiac gastric. The lymph nodes were considered metastatic in above regions. 2)The pathological results of the lymph nodes dissected compared to the RII result. The metastatic lymph nodes were found in the regions of dispersedly concentrated radioactivity, while no metastatic lymph nodes could be found in the radioactivity free regions. 3)After counting for radioactivity, lymph node metastases showed higher antibody uptake than the non-metastases lymph nodes. The difference was statistically significant. Conclusion: 131I-G9 may be used to locate metastatic lymph nodes in patients with esophageal carcinoma.