药学服务与研究
藥學服務與研究
약학복무여연구
PHARMACEUTICAL CARE AND RESEARCH
2010年
1期
59-62
,共4页
帕洛诺司琼%5-HT_3受体拮抗剂%呕吐,化疗%综述
帕洛諾司瓊%5-HT_3受體拮抗劑%嘔吐,化療%綜述
파락낙사경%5-HT_3수체길항제%구토,화료%종술
palonosetron%5-HT_3 receptor antagonist%vomiting,chemotherapy%review
帕洛诺司琼是第一个获准用于预防迟发性化疗所致恶心、呕吐(chemotherapy-induced nausea and vomiting, CINV)的5-羟色胺3(5-HT_3)受体拮抗剂.通过比较,发现帕洛诺司琼治疗急性期CINV至少同第一代5-HT_3受体拮抗剂同样有效,对延迟性CINV的疗效优于第一代5-HT_3受体拮抗剂.本文综述了帕洛诺司琼的临床研究进展,并探讨了多剂量给予帕洛诺司琼的安全性和有效性.
帕洛諾司瓊是第一箇穫準用于預防遲髮性化療所緻噁心、嘔吐(chemotherapy-induced nausea and vomiting, CINV)的5-羥色胺3(5-HT_3)受體拮抗劑.通過比較,髮現帕洛諾司瓊治療急性期CINV至少同第一代5-HT_3受體拮抗劑同樣有效,對延遲性CINV的療效優于第一代5-HT_3受體拮抗劑.本文綜述瞭帕洛諾司瓊的臨床研究進展,併探討瞭多劑量給予帕洛諾司瓊的安全性和有效性.
파락낙사경시제일개획준용우예방지발성화료소치악심、구토(chemotherapy-induced nausea and vomiting, CINV)적5-간색알3(5-HT_3)수체길항제.통과비교,발현파락낙사경치료급성기CINV지소동제일대5-HT_3수체길항제동양유효,대연지성CINV적료효우우제일대5-HT_3수체길항제.본문종술료파락낙사경적림상연구진전,병탐토료다제량급여파락낙사경적안전성화유효성.
Palonosetron is the first 5-HT_3 receptor antagonist approved for prevention of delayed chemotherapy-induced nausea and vomiting(CINV).Furthermore, palonosetron is at least as effective as first-generation 5-HT_3 receptor antagonists in treatment of acute CINV, and is more effective than first-generation 5-HT_3 receptor antagonists in treatment of delayed CINV. The progress of clinical study of palonosetron is reviewed in this article,and the safety and efficacy of multi-dose of palonosetron in treatment of CINV are also discussed.
