中华妇幼临床医学杂志（电子版）
中華婦幼臨床醫學雜誌（電子版）
중화부유림상의학잡지（전자판）
CHINESE JOURNAL OF OBSTETRICS & GYNECOLOGY AND PEDIATRICS(ELECTRONIC VERSION)
2012年
4期
369-371
,共3页
糖链抗原-125%卵巢子宫内膜异位囊肿%血清
糖鏈抗原-125%卵巢子宮內膜異位囊腫%血清
당련항원-125%란소자궁내막이위낭종%혈청
carbohydrate antigent-125%endometrial cysts of the ovary%serum
目的 探讨血清糖链抗原-125 (CA125)与卵巢子宫内膜异位囊肿(ECO)的关系.方法 选择2009年7月至2010年12月于本院妇科诊治的62例ECO患者为研究对象,纳入研究组;选择同期在本院住院手术治疗的卵巢良性囊肿[不合并子宫内膜异位症(EMs)]患者62例,纳入对照组,均经术后组织病理学检查结果证实(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象本人的知情同意,并与之签署临床研究知情同意书).两组患者年龄、体重指数(BMI)等比较,差异无统计学意义(P＞0.0 5).采用微粒子酶免疫分析法分别测定两组患者的血清CA125水平,并进行相关统计学分析.结果 研究组血清CA125水平显著高于对照组[(95.36±56.31)U/mL vs.(18.64±7.45) U/mL],两组比较,差异有统计学意义(P＜0.01).研究组血清CA125水平与EMs分期(病情严重程度)呈显著正相关关系(r=0.8832,P＜0.01),并且EMsⅡ～Ⅳ期患者的血清CA125水平较EMs Ⅰ期显著升高,差异有统计学意义(P＜0.01);EMsⅡ期与EMsⅢ期患者血清CA125水平比较,差异亦有统计学意义(P＜0.01).研究组血清CA125水平与痛经评分(DSS)呈正相关关系(r=0.5650,P＜0.01),并且DSS为1～3分患者与0分患者的血清CA125水平比较,差异均有统计学意义(P＜0.01).结论 血清CA125与ECO的发生发展及预后有关.ECO患者的血清CA125水平随着EMs分期(EMs严重程度)增加而升高,与DSS均呈正相关关系.测定血清CA125有助于对ECO的诊断及对病情、预后的判断.
目的 探討血清糖鏈抗原-125 (CA125)與卵巢子宮內膜異位囊腫(ECO)的關繫.方法 選擇2009年7月至2010年12月于本院婦科診治的62例ECO患者為研究對象,納入研究組;選擇同期在本院住院手術治療的卵巢良性囊腫[不閤併子宮內膜異位癥(EMs)]患者62例,納入對照組,均經術後組織病理學檢查結果證實(本研究遵循的程序符閤本院人體試驗委員會所製定的倫理學標準,得到該委員會批準,分組徵得受試對象本人的知情同意,併與之籤署臨床研究知情同意書).兩組患者年齡、體重指數(BMI)等比較,差異無統計學意義(P＞0.0 5).採用微粒子酶免疫分析法分彆測定兩組患者的血清CA125水平,併進行相關統計學分析.結果 研究組血清CA125水平顯著高于對照組[(95.36±56.31)U/mL vs.(18.64±7.45) U/mL],兩組比較,差異有統計學意義(P＜0.01).研究組血清CA125水平與EMs分期(病情嚴重程度)呈顯著正相關關繫(r=0.8832,P＜0.01),併且EMsⅡ～Ⅳ期患者的血清CA125水平較EMs Ⅰ期顯著升高,差異有統計學意義(P＜0.01);EMsⅡ期與EMsⅢ期患者血清CA125水平比較,差異亦有統計學意義(P＜0.01).研究組血清CA125水平與痛經評分(DSS)呈正相關關繫(r=0.5650,P＜0.01),併且DSS為1～3分患者與0分患者的血清CA125水平比較,差異均有統計學意義(P＜0.01).結論 血清CA125與ECO的髮生髮展及預後有關.ECO患者的血清CA125水平隨著EMs分期(EMs嚴重程度)增加而升高,與DSS均呈正相關關繫.測定血清CA125有助于對ECO的診斷及對病情、預後的判斷.
목적 탐토혈청당련항원-125 (CA125)여란소자궁내막이위낭종(ECO)적관계.방법 선택2009년7월지2010년12월우본원부과진치적62례ECO환자위연구대상,납입연구조;선택동기재본원주원수술치료적란소량성낭종[불합병자궁내막이위증(EMs)]환자62례,납입대조조,균경술후조직병이학검사결과증실(본연구준순적정서부합본원인체시험위원회소제정적윤리학표준,득도해위원회비준,분조정득수시대상본인적지정동의,병여지첨서림상연구지정동의서).량조환자년령、체중지수(BMI)등비교,차이무통계학의의(P＞0.0 5).채용미입자매면역분석법분별측정량조환자적혈청CA125수평,병진행상관통계학분석.결과 연구조혈청CA125수평현저고우대조조[(95.36±56.31)U/mL vs.(18.64±7.45) U/mL],량조비교,차이유통계학의의(P＜0.01).연구조혈청CA125수평여EMs분기(병정엄중정도)정현저정상관관계(r=0.8832,P＜0.01),병차EMsⅡ～Ⅳ기환자적혈청CA125수평교EMs Ⅰ기현저승고,차이유통계학의의(P＜0.01);EMsⅡ기여EMsⅢ기환자혈청CA125수평비교,차이역유통계학의의(P＜0.01).연구조혈청CA125수평여통경평분(DSS)정정상관관계(r=0.5650,P＜0.01),병차DSS위1～3분환자여0분환자적혈청CA125수평비교,차이균유통계학의의(P＜0.01).결론 혈청CA125여ECO적발생발전급예후유관.ECO환자적혈청CA125수평수착EMs분기(EMs엄중정도)증가이승고,여DSS균정정상관관계.측정혈청CA125유조우대ECO적진단급대병정、예후적판단.
Objective To study the relationship between serum carbohydrate antigent-125(CA125) and endometrial cysts of ovary(ECO).Methods From 2009 July to 2010 December,a total of 62 cases women with ECO were included in study group,during the same period and in the same hospital,62 cases with endometriosis (EMs) benign ovarian cysts included in control group,all accepted operation treatment and confirmed by postoperative histopathological examination.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Chengdu Women and Children's Central Hospital.Informed consent was obtained from all participants. There had no significance difference between two groups among ages,body mass index(BMI) and etc.(P＞0.05).Levels of serum CA125 in two groups were measured by microparticle enzyme immunoassay,and analysis by statistics methods. Results Levels of serum CA125 in study group were significantly higher than those in control group [(95.36±56.31) U/mL vs.(18.64± 7.45) U/mL],There had significance difference (P＜0.01).In study group,the relationship between levels of serum CA125 and severity of EMs (EMs stages) had a positive correlation (r=0.8832,P＜0.01);serum CA125 levels in patients of EMs Ⅱ-Ⅳ stages were much higher than those in EMs Ⅰ stage,and there had significant difference(P＜0.01),and here had significance difference between levels of serum CA125 in EMs Ⅱ stage and Ⅲ stage (P＜0.01) ;levels of serum CA125 and dysmenorrhea severity had a positive correlation (r=0.5650,P＜ 0.01),and there had significance difference between levels of dysmenorrhea severity scores (DSS) 1-3 and 0 (P＜ 0.01).In study group,relationship between levels of serum CA125 and dysmenorrhea severity also had a positively correlated (P＜0.01).Conclusions Levels of serum CA125 has bearing on the occurrence,development and prognosis of EOC,Levels of serum CA125 had a positively correlated with EMs stages and DSS.
