国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2012年
16期
2491-2494
,共4页
骨质疏松(osteoporosis)%骨密度(BMD)%胰岛素样生长因子(insulin-growth-factor IGF)%肿瘤坏死因子(tumour necrosis factor TNF)
骨質疏鬆(osteoporosis)%骨密度(BMD)%胰島素樣生長因子(insulin-growth-factor IGF)%腫瘤壞死因子(tumour necrosis factor TNF)
골질소송(osteoporosis)%골밀도(BMD)%이도소양생장인자(insulin-growth-factor IGF)%종류배사인자(tumour necrosis factor TNF)
Osteoporosis%Bone mineral density (BMD)%Insulin-like growth factor (IGF)%Tumour necrosis factor (TNF)
在过去的几年时间里,关于胰岛素样生长因子系统在骨骼再建中的作用得到了充分的肯定.在这里我们应用充分的证据说明由骨细胞所产生的IGF-1和IGF-2在调节成骨细胞和破骨细胞中所起的作用,另外,我们也回顾了几个实验室所做的关于胰岛素样生长因子系统的实验结果.有证据表明,其他调节骨代谢的通过IGF系统发挥作用.骨骼局部的IGF-1和IGF-2在骨再建中的作用众所周知,但是关于循环系统中IGF 的作用仍然不是十分明了.有新的研究结果表明血清中的生长因子也起到了一定的作用,最后我们回顾了目前比较公认的重组IGFs对骨再建的作用,然而,关于IGFs对骨值疏松的最终的治疗效果仍有待于进一步研究.
在過去的幾年時間裏,關于胰島素樣生長因子繫統在骨骼再建中的作用得到瞭充分的肯定.在這裏我們應用充分的證據說明由骨細胞所產生的IGF-1和IGF-2在調節成骨細胞和破骨細胞中所起的作用,另外,我們也迴顧瞭幾箇實驗室所做的關于胰島素樣生長因子繫統的實驗結果.有證據錶明,其他調節骨代謝的通過IGF繫統髮揮作用.骨骼跼部的IGF-1和IGF-2在骨再建中的作用衆所週知,但是關于循環繫統中IGF 的作用仍然不是十分明瞭.有新的研究結果錶明血清中的生長因子也起到瞭一定的作用,最後我們迴顧瞭目前比較公認的重組IGFs對骨再建的作用,然而,關于IGFs對骨值疏鬆的最終的治療效果仍有待于進一步研究.
재과거적궤년시간리,관우이도소양생장인자계통재골격재건중적작용득도료충분적긍정.재저리아문응용충분적증거설명유골세포소산생적IGF-1화IGF-2재조절성골세포화파골세포중소기적작용,령외,아문야회고료궤개실험실소주적관우이도소양생장인자계통적실험결과.유증거표명,기타조절골대사적통과IGF계통발휘작용.골격국부적IGF-1화IGF-2재골재건중적작용음소주지,단시관우순배계통중IGF 적작용잉연불시십분명료.유신적연구결과표명혈청중적생장인자야기도료일정적작용,최후아문회고료목전비교공인적중조IGFs대골재건적작용,연이,관우IGFs대골치소송적최종적치료효과잉유대우진일보연구.
Objective In the last five years significant progress has been made in defining the role of insulin like growth factors (IGFs) in the process of bone remodeling.In this paper,we present critical evidence that IGF-Ⅰ and IGF Ⅱ are produced by bone cells and regulate specific osteoclastic functions.In addition,we review work from several labora tories establishing the role of the skeletal IGF binding proteins as an integral component of a unique IGF regulatory system.According to related evidences,the bone remodeling process may exert their effects through the IGF regulatory system.In contrast to the well-defined local action of IGF-Ⅰ and IGF-Ⅱ on the skeleton,the relationship between circulating IGF-Ⅰand bone remodeling is less certain.Newer research results show that the potential utility of serum growth factor measure ments have certain effects in clinical states.Finally,this paper presents an overview of the most current efforts to stimulate bone formation using recombinant IGFs.However,work on the beneficial aspects of IGFs for the skeleton remains prelimi nary at best with the eventual therapeutic role of IGF-Ⅰ in osteoporosis yet to be defined.
