CAJ | 학술논문

多囊卵巢综合征(PCOS)的一个重要发生机制是胰岛素抵抗.二甲双胍可增加胰岛素敏感性,重建月经周期,促进排卵,减轻高雄激素血症,降低体重.预防和延缓妊娠糖尿病以及2型糖尿病的发生、发展,减少心脑血管疾病的危险因素.与克罗米芬、口服避孕药、手术等传统治疗方法相比,二甲双胍具有明显的优势,可作为PCOS患者的一种长期治疗方案.
다낭란소종합정(PCOS)적일개중요발생궤제시이도소저항.이갑쌍고가증가이도소민감성,중건월경주기,촉진배란,감경고웅격소혈증,강저체중.예방화연완임신당뇨병이급2형당뇨병적발생、발전,감소심뇌혈관질병적위험인소.여극라미분、구복피잉약、수술등전통치료방법상비,이갑쌍고구유명현적우세,가작위PCOS환자적일충장기치료방안.
Since insulin resistance plays an important role in the development of polycystic ovary syndrome (PCOS), metformin as an insulin sensitizer has been found to have a positive effect on the treatment of PCOS,including augmenting insulin sensitivity,restoring menstrual cycle,promoting ovulation,ameliorating the effects of androgen excess, reducing weight, optimizing metabolic parameters, preventing or delaying the development of gestational diabetes and type 2 diabetes and reducing the risk factors of cardiovascular disease. Metformin has advantages compared with traditional therapies such as clomiphene,oral contraceptive agent and surgery. So it could be used as a