CAJ | 학술논문

目的探讨胃癌组织中黏附分子CD44v3和血管内皮生长因子C(VEGF-C)的表达及其临床意义.方法应用免疫组织化学SP法检测92例胃癌组织中CD44v3和VEGF-C的表达情况.结果胃癌组织CD44v3阳性表达率为27.2%,在不同性别、部位、浸润深度、WHO分型、Lauren分型、有无远处器官转移组之间,差异均无统计学意义(均P＞0.05),而与淋巴结转移状况、组织分化密切相关,差异有统计学意义(均P＜0.05);胃癌组织中VEGF-C阳性表达率为48.9%,在不同性别、部位、分化程度、浸润深度、WHO分型、有无远处器官转移组之间,差异均无统计学意义(均P＞0.05),而与Lauren分型、淋巴结转移密切相关,差异均有统计学意义(均P＜0.05).Cox-Regression分析显示对生存率有影响的因子只有淋巴结转移情况(P=0.015).结论检测44v3和VEGF-C表达对预测胃癌病程进展和胃癌转移潜能有一定价值,但对患者的生存率并无影响;两者在促进胃癌的转移方面并无协同作用.
목적 탐토위암조직중점부분자CD44v3화혈관내피생장인자C(VEGF-C)적표체급기림상의의.방법 응용면역조직화학SP법검측92례위암조직중CD44v3화VEGF-C적표체정황.결과 위암조직CD44v3양성표체솔위27.2%,재불동성별、부위、침윤심도、WHO분형、Lauren분형、유무원처기관전이조지간,차이균무통계학의의(균P＞0.05),이여림파결전이상황、조직분화밀절상관,차이유통계학의의(균P＜0.05);위암조직중VEGF-C양성표체솔위48.9%,재불동성별、부위、분화정도、침윤심도、WHO분형、유무원처기관전이조지간,차이균무통계학의의(균P＞0.05),이여Lauren분형、림파결전이밀절상관,차이균유통계학의의(균P＜0.05).Cox-Regression분석현시대생존솔유영향적인자지유림파결전이정황(P=0.015).결론 검측44v3화VEGF-C표체대예측위암병정진전화위암전이잠능유일정개치,단대환자적생존솔병무영향;량자재촉진위암적전이방면병무협동작용.
Objective To investigate the expression of CD44v3 and VEGF-C in human gastric cancers and the clinical significance. Methods The expression of CD44v3 and VEGF-C was detected by immunohistochemistry SP method in 92 gastric cancer tissues. Results Positive immunohistochemical stain for CD44v3 was identified in 27.2% of gastric cancer tissues. There was no correlation found among the expression of CD44v3 with sex, location,depth of invasion, WHO type, Lauren type as well as distant metastasis (all P ＞ 0. 05 ). The expression of CD44v3 was positively correlated with lymph node metastasis and tumor differentiation( all P ＜ 0. 05 ). Positive immunohistochemical stain for VEGF-C was identified in 48.9% of gastric cancer tissues. There was no correlation found among the expression of VEGF-C with sex,location, tumor differentiation, depth of invasion, WHO type, as well as distant metastasis ( all P ＞ 0. 05 ). The expression of VEGF-C was positively correlated with lymph node metastasis and Lauren type ( all P ＜0. 05). Cox-Regression reflected that only the lymphatic metastasis situation correlated with the life ratio( P =0. 015). Conclusion The expression of CD44v3 and VEGF-C could suggest the progression and metastatic potential value of gastric cancer,but didnt correlate with the life ratio. There was no cooperation between CD44v3 and VEGF-C in promoting gastric cancer metastasis.