中华核医学与分子影像杂志
中華覈醫學與分子影像雜誌
중화핵의학여분자영상잡지
Chinese Journal of Nuclear Medicine and Molecular Imaging
2012年
5期
345-348
,共4页
弓健%邓梅%宋元宗%徐浩
弓健%鄧梅%宋元宗%徐浩
궁건%산매%송원종%서호
胆汁郁积,肝内%婴儿,新生%放射性核素显像%锝%EHIDA
膽汁鬱積,肝內%嬰兒,新生%放射性覈素顯像%锝%EHIDA
담즙욱적,간내%영인,신생%방사성핵소현상%득%EHIDA
Cholestasis,intrahepatic%Infant,newborn%Radionuclide imaging%Technetium%EHIDA
目的 研究citrin缺陷导致的新生儿肝内胆汁淤积症(NICCD)99Tcm-EHIDA肝胆动态显像特点及临床价值.方法 分别对NICCD组(12例)和NICCD阴性对照组(5例,4例婴儿肝炎综合征和1例脂类代谢异常)患儿[年龄分别为(127±27)d和(164±15)d]进行99Tcm-EHIDA肝胆动态显像,观察注射显像剂后肝脏及肠道放射性分布,并采用秩和检验比较2组肝影持续时间及肠道显影时间.结果 NICCD组肠道显影时间和肝影持续时间均在180～1440min(中位数均为360min),而对照组肠道显影时间在15～30min(中位数为15min),肝影持续时间在60～180min(中位数为60min).NICCD患儿肝影持续时间及肠道显影时问均明显延长(Z=-3.20和-3.17,P均＜0.05).3例NICCD患儿肝显影不清晰,其中1例NICCD患儿胆囊及肠道在24h内始终未见显影,治疗后该患儿肝胆动态显像示肝摄取及排泄功能明显改善,15min肠道显影.结论 99Tcm-EHIDA肝胆动态显像示NICCD患儿肝脏摄取和排泄功能降低,提示99Tcm-EHIDA肝胆动态显像在NICCD诊断中可作为辅助检查手段.
目的 研究citrin缺陷導緻的新生兒肝內膽汁淤積癥(NICCD)99Tcm-EHIDA肝膽動態顯像特點及臨床價值.方法 分彆對NICCD組(12例)和NICCD陰性對照組(5例,4例嬰兒肝炎綜閤徵和1例脂類代謝異常)患兒[年齡分彆為(127±27)d和(164±15)d]進行99Tcm-EHIDA肝膽動態顯像,觀察註射顯像劑後肝髒及腸道放射性分佈,併採用秩和檢驗比較2組肝影持續時間及腸道顯影時間.結果 NICCD組腸道顯影時間和肝影持續時間均在180～1440min(中位數均為360min),而對照組腸道顯影時間在15～30min(中位數為15min),肝影持續時間在60～180min(中位數為60min).NICCD患兒肝影持續時間及腸道顯影時問均明顯延長(Z=-3.20和-3.17,P均＜0.05).3例NICCD患兒肝顯影不清晰,其中1例NICCD患兒膽囊及腸道在24h內始終未見顯影,治療後該患兒肝膽動態顯像示肝攝取及排洩功能明顯改善,15min腸道顯影.結論 99Tcm-EHIDA肝膽動態顯像示NICCD患兒肝髒攝取和排洩功能降低,提示99Tcm-EHIDA肝膽動態顯像在NICCD診斷中可作為輔助檢查手段.
목적 연구citrin결함도치적신생인간내담즙어적증(NICCD)99Tcm-EHIDA간담동태현상특점급림상개치.방법 분별대NICCD조(12례)화NICCD음성대조조(5례,4례영인간염종합정화1례지류대사이상)환인[년령분별위(127±27)d화(164±15)d]진행99Tcm-EHIDA간담동태현상,관찰주사현상제후간장급장도방사성분포,병채용질화검험비교2조간영지속시간급장도현영시간.결과 NICCD조장도현영시간화간영지속시간균재180～1440min(중위수균위360min),이대조조장도현영시간재15～30min(중위수위15min),간영지속시간재60～180min(중위수위60min).NICCD환인간영지속시간급장도현영시문균명현연장(Z=-3.20화-3.17,P균＜0.05).3례NICCD환인간현영불청석,기중1례NICCD환인담낭급장도재24h내시종미견현영,치료후해환인간담동태현상시간섭취급배설공능명현개선,15min장도현영.결론 99Tcm-EHIDA간담동태현상시NICCD환인간장섭취화배설공능강저,제시99Tcm-EHIDA간담동태현상재NICCD진단중가작위보조검사수단.
Objective To evaluate the imaging characteristics of 99Tcm-EHIDA hepatobiliary scintigraphy in neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD).Methods 99Tcm-EHIDA hepatobiliary scan was performed on 12 NICCD infants (aged (127 ±27) d) and 5 infants as a control group (including 4 cases with hepatitis syndrome and 1 with abnormal lipid metabolism,aged (164 ± 15) d).The differences of hepatic activity retention time and bowel activity visualization time bctwccn the two groups were observed.The two-sample Wilcoxon rank sum test was used to analyze the data.Results In the NICCD group,both hepatic activity retention time and bowel activity visualization time were 180-1440 min (median =360 min).In the control group,hepatic activity retention time and bowel activity visualization time were 60-180 min (median =60 min) and 15-30 min (median =15 min),respectively.The differences of hepatic activity retention time and bowel activity visualization time between the two groups were statistically significant (Z =-3.20 and-3.17,both P ＜ 0.05).Three NICCD infants showed minimal hepatic uptake of the tracer.The bowel activity was not visible in 1 NICCD case.The hepatic uptake and biliary excretion function of this infant were significantly improved on hepatobiliary scintigraphy after treatment,with a bowel activity visualization time of 15 min.Conclusion NICCD infants show impaired hepatic uptake and biliary excretion function on 99Tcm-EHIDA hepatobiliary imaging,which may be used in NICCD diagnosis and treatment response evaluation.
