CAJ | 학술논문

目的研究血小板活化对肺癌病情和预后的影响.方法采用放射免疫法和酶联免疫法测定168例肺癌(肺癌组)和80例健康人(对照组)血浆血栓烷B_2(TXB_2)、11-去氢-血栓烷B_2(DH-TXB_2)、凝血酶敏感蛋白(TSP)、β-血小板球蛋白(β-TG)、血小板α-颗粒膜蛋白(GMP-140)、环磷酸乌苷(CGMP)和血清纤维结合蛋白(FN)含量.结果 (1)与对照组比较:肺癌早、中期组DH-TXB_2、TSP、β-TG、GMP-140、CGMP升高,FN降低;肺癌晚期组TXB_2、DH-TXB_2、TSP、β-TG、GMP-140、CGMP升高,FN降低;手术后组GMP-140升高.(2)与早、中期组比较:手术后组DH-TXB_2、TSP、β-TG、GMP-140、CGMP降低,FN升高;晚期组TXB_2、DH-TXB_2、TSP、β-TG、GMP-140、CGMP升高,FN降低.(3)肺癌组CGMP与DH-TXB_2、TSP、β-TG、GMP-140之间均呈正相关.(4)与对照组比较:腺癌、小细胞癌TXB_2、DH-TXB_2、TSP、β-TG、GMP-140、CGMP升高,FN降低;鳞癌TXB_2、DH-TXB_2、GMP-140、CGMP升高,FN降低.(5)与小细胞癌比较:腺癌 DH-TXB_2降低;鳞癌GMP-140降低.结论肺癌患者血小板广泛激活,晚期病例激活较重.手术后血小板活化显著减轻.部分血小板活化分子标志物水平可能与肺癌组织学类型有关.
목적 연구혈소판활화대폐암병정화예후적영향.방법 채용방사면역법화매련면역법측정168례폐암(폐암조)화80례건강인(대조조)혈장혈전완B_2(TXB_2)、11-거경-혈전완B_2(DH-TXB_2)、응혈매민감단백(TSP)、β-혈소판구단백(β-TG)、혈소판α-과립막단백(GMP-140)、배린산오감(CGMP)화혈청섬유결합단백(FN)함량.결과 (1)여대조조비교:폐암조、중기조DH-TXB_2、TSP、β-TG、GMP-140、CGMP승고,FN강저;폐암만기조TXB_2、DH-TXB_2、TSP、β-TG、GMP-140、CGMP승고,FN강저;수술후조GMP-140승고.(2)여조、중기조비교:수술후조DH-TXB_2、TSP、β-TG、GMP-140、CGMP강저,FN승고;만기조TXB_2、DH-TXB_2、TSP、β-TG、GMP-140、CGMP승고,FN강저.(3)폐암조CGMP여DH-TXB_2、TSP、β-TG、GMP-140지간균정정상관.(4)여대조조비교:선암、소세포암TXB_2、DH-TXB_2、TSP、β-TG、GMP-140、CGMP승고,FN강저;린암TXB_2、DH-TXB_2、GMP-140、CGMP승고,FN강저.(5)여소세포암비교:선암 DH-TXB_2강저;린암GMP-140강저.결론 폐암환자혈소판엄범격활,만기병례격활교중.수술후혈소판활화현저감경.부분혈소판활화분자표지물수평가능여폐암조직학류형유관.
Objective To study the effects of platelet activation on the metastasis and prognoies of lung cancer. Methods Radio-immunity and ELISA were employed to detect the TXB_2,DH-TXB_2,TSP, β-TG, GMP-140,CGMP and FN of 168 cases of lung cancer patients (lung cancer group) and 80 cases of healthy persons control group. The lung cancer group included two subgroups: earlier and metaphase group (n=51) and advanced group (n=17), 39 cases in the former group underwent operation (after operation group). Results (1)Compared with control group, the levels of DH-TXB2,TSP,β-TG,GMP-140,CGMP in group of earlier and metaphase lung cancer increased and FN decreased. TXB2,DH-TXB2,TSP,β-TG,GMP-140,CGMP in advanced group increased and FN decreased;DH-TXB2 and GMP-140 increased in group of after operation. (2)Compared with group of earlier and metaphase lung cancer,the levels of DH-TXB2,TSP,β-TG,GMP-140,CGMP in group of after operation increased and FN decreased; In advanced group, levels of TXB2, DH-TXB2,TSP,β-TG,GMP-140,CGMP increased and FN decreased. (3)In the lung cancer group, CGMP was positively correlated with DH-TXB2,TSP,β-TG and GMP-140. (4)Compared with control group,TXB2, DH-TXB2, TSP,β-TG,GMP-140 and CGMP in group glandular cancer and small cell carcinoma cases increased,FN decreased;In squamous cancer, the levels of TXB2, DH-TXB2,GMP-140 and CGMP increased and FN decreased. (5)Compared with small cell carcinoma cases, DH-TXB2 decreased in cases of glandular cancer; GMP-140 decreased in squamous cancer. Conclusions Activations of platelet generally emerged with lung cancer patients, platelet activation was severe in advanced cancer patients. Activations of platelet, after operation, is obviously eased. The level of platelet activation marker is possibly related with histological classification of lung cancer.