CAJ | 학술논문

目的研究HER-2/neu在肝细胞癌(HCC)患者中的表达及其临床意义.方法应用免疫组织化学SP法检测30例HCC、10例肝硬化、10例正常肝组织中HER-2蛋白的表达情况.结果 HCC中HER-2阳性表达率显著高于肝硬化及正常肝组织(X~2=6.482,P=0.032);HCC中HER-2的表达与是否伴有肝硬化(P=0.041)、侵袭性(P=0.028)、Edmondson分级(P=0.012)有明显的相关性,与其他临床病理特征无明显相关性.HER-2表达阳性患者的平均生存时间明显短于阴性表达患者(P=0.036).结论HER-2/neu基因在HCC的侵袭性生长转移和发展中可能具有一定的促进作用,在HCC组织中HER-2/neu表达阳性的患者预示较差的预后.
목적 연구HER-2/neu재간세포암(HCC)환자중적표체급기림상의의.방법 응용면역조직화학SP법검측30례HCC、10례간경화、10례정상간조직중HER-2단백적표체정황.결과 HCC중HER-2양성표체솔현저고우간경화급정상간조직(X~2=6.482,P=0.032);HCC중HER-2적표체여시부반유간경화(P=0.041)、침습성(P=0.028)、Edmondson분급(P=0.012)유명현적상관성,여기타림상병리특정무명현상관성.HER-2표체양성환자적평균생존시간명현단우음성표체환자(P=0.036).결론HER-2/neu기인재HCC적침습성생장전이화발전중가능구유일정적촉진작용,재HCC조직중HER-2/neu표체양성적환자예시교차적예후.
Objective To investigate the expression of human epidennal growth factor receptor 2 (HER-2/neu) in hepatocellular carcinoma (HCC) patients and its clinical significance. Methods The expressions of HER-2/neu were detected by SP immunohistochemistry method in 30 patients with HCC, 10 with portal cirrhosis of the liver and 10 with normal livu.Results The positivity rate of HER-2/neu was markedly higher in HCC patients than in those with portal cirrhosis and normal liver (X~2=6.482, P=0.032). The expression of HER-2/neu was closely correlated to portal cirrhosis of the liver (P=0.041), tumor invasion (P=0 .028) and Edmondson grades (P=0 .012). The average survivaltime was significant shorter in patients with HER-2/neu-positive tumor than in those with HER-2/neu-negative tumor (P=0.036). Conclusion The expression of HER-2/neu may play a role in the invasion, metastasis and progression of HCC. The patients positive for HER-2/neu in the HCC tissues have generally poor prognosis.