中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2008年
4期
245-249
,共5页
红斑狼疮,系统性%血清%骨桥蛋白
紅斑狼瘡,繫統性%血清%骨橋蛋白
홍반랑창,계통성%혈청%골교단백
Lupus erythematosus,systemic%Serum%Osteopontin
目的 研究血清骨桥蛋白(OPN)与系统性红斑狼疮(SLE)临床表现、实验指标、疾病活动的相关性,探讨血清OPN在SLE中的意义及SLE的发病机制.方法 用酶联免疫吸附(ELISA)法检测68例SLE患者和20名正常对照组血清中OPN的水平,并监测SLE患者的临床表现及实验室指标,分析其与OPN的相关性.结果 68例SLE患者中79%血清OPN阳性,20名正常对照组0PN均阴性,SLE组患者血清OPN阳性率及OPN水平显著高于正常对照组(P＜0.01).血清OPN阳性组的SLE患者与OPN阴性组的SLE患者相比,在年龄、性别及病程上差异均无统计学意义(P＞O.05 .血清OPN阳性组SLE患者发热、脱发、白细胞降低、肝脏损害、补体C4降低、免疫球蛋白IgA增高、蛋白尿及抗dsDNA抗体阳性的发生率明显高于OPN阴性组(P＜0.05). SLE患者血清OPN阳性率明显高于抗dsDNA抗体、抗sm抗体的阳性率,差异具有统计学意义(P＜0.01). SLE患者血清OPN水平与SLE疾病活动指数(SLEDAI)积分呈明显的正相关(r=0.292;P＜0.05);SLE活动期患者血清OPN阳性率及水平明显高于SLE缓解期患者,两组比较差异具有统计学意义(P＜O.05).结论 SLE患者血清中OPN水平升高,与SLE疾病活动性密切相关,可作为SLE的病情活动指标.
目的 研究血清骨橋蛋白(OPN)與繫統性紅斑狼瘡(SLE)臨床錶現、實驗指標、疾病活動的相關性,探討血清OPN在SLE中的意義及SLE的髮病機製.方法 用酶聯免疫吸附(ELISA)法檢測68例SLE患者和20名正常對照組血清中OPN的水平,併鑑測SLE患者的臨床錶現及實驗室指標,分析其與OPN的相關性.結果 68例SLE患者中79%血清OPN暘性,20名正常對照組0PN均陰性,SLE組患者血清OPN暘性率及OPN水平顯著高于正常對照組(P＜0.01).血清OPN暘性組的SLE患者與OPN陰性組的SLE患者相比,在年齡、性彆及病程上差異均無統計學意義(P＞O.05 .血清OPN暘性組SLE患者髮熱、脫髮、白細胞降低、肝髒損害、補體C4降低、免疫毬蛋白IgA增高、蛋白尿及抗dsDNA抗體暘性的髮生率明顯高于OPN陰性組(P＜0.05). SLE患者血清OPN暘性率明顯高于抗dsDNA抗體、抗sm抗體的暘性率,差異具有統計學意義(P＜0.01). SLE患者血清OPN水平與SLE疾病活動指數(SLEDAI)積分呈明顯的正相關(r=0.292;P＜0.05);SLE活動期患者血清OPN暘性率及水平明顯高于SLE緩解期患者,兩組比較差異具有統計學意義(P＜O.05).結論 SLE患者血清中OPN水平升高,與SLE疾病活動性密切相關,可作為SLE的病情活動指標.
목적 연구혈청골교단백(OPN)여계통성홍반랑창(SLE)림상표현、실험지표、질병활동적상관성,탐토혈청OPN재SLE중적의의급SLE적발병궤제.방법 용매련면역흡부(ELISA)법검측68례SLE환자화20명정상대조조혈청중OPN적수평,병감측SLE환자적림상표현급실험실지표,분석기여OPN적상관성.결과 68례SLE환자중79%혈청OPN양성,20명정상대조조0PN균음성,SLE조환자혈청OPN양성솔급OPN수평현저고우정상대조조(P＜0.01).혈청OPN양성조적SLE환자여OPN음성조적SLE환자상비,재년령、성별급병정상차이균무통계학의의(P＞O.05 .혈청OPN양성조SLE환자발열、탈발、백세포강저、간장손해、보체C4강저、면역구단백IgA증고、단백뇨급항dsDNA항체양성적발생솔명현고우OPN음성조(P＜0.05). SLE환자혈청OPN양성솔명현고우항dsDNA항체、항sm항체적양성솔,차이구유통계학의의(P＜0.01). SLE환자혈청OPN수평여SLE질병활동지수(SLEDAI)적분정명현적정상관(r=0.292;P＜0.05);SLE활동기환자혈청OPN양성솔급수평명현고우SLE완해기환자,량조비교차이구유통계학의의(P＜O.05).결론 SLE환자혈청중OPN수평승고,여SLE질병활동성밀절상관,가작위SLE적병정활동지표.
Objective To explore the clinical significance of osteopontin (OPN) in systemic lupus erythematosus (SLE) and its pathogenic role in SLE by studying the correlation between OPN and clinical manifestations,laboratory parameters and disease activity.Methods The enzyme-linked immunosorbent assay(ELISA)was used to measure the level of OPN in serum of 68 SLE patients and 20 healthy controls.the clin-ical data and laboratory parameters were recorded.Results The positive rate of OPN was 79.41%in 68 SLEpatients and could not be detected in healthy controls.Compared with healthy controls.the positive rate and level of OPN in SLE patients was significantly higher(P＜0.01).There was no significant difference in age.gender and disease duration between OPN positive and negative lupus patients(P＞0.05).The Drevalence of fever,hair loss,WBC decrease,liver damage,serum C4 decrease,proteinuria and anti-dsDNA antibody in OPN positive SLE were significantly higher than those of OPN negative SLE(P＜0.05).The positive rate of serum OPN in SLE patients was significantly higher than that of anti-dsDNA antibody and anti-Sm antibody (P＜0.01).The level of plasma OPN was associated with systemic lupus erythematosus disease activity index (SLEDAI)(r=0.292,P＜0.05).The positive rate and level of OPN in active SLE patients was significantly higher than that of inactive SLE patients(P＜O.05).Conclusion The level of plasma OPN has a close rela-tionship with the activity of SLE.It may serve as an active disease marker of SLE.
