中华口腔正畸学杂志
中華口腔正畸學雜誌
중화구강정기학잡지
CHINESE JOURNAL OF ORTHODONTICS
2010年
3期
140-143
,共4页
正畸治疗%牙龈增生%口腔卫生
正畸治療%牙齦增生%口腔衛生
정기치료%아간증생%구강위생
Orthodontic treatment%Gingival enlargement%Oral hygiene
目的 探讨正畸治疗中牙龈增生的相关致病因素.方法 12例因接受固定正畸治疗而出现牙龈增生的患者纳入牙龈增生组,对照组为12例牙龈健康者.分别于基线时采集两组研究对象的牙周检查指标、龈下菌斑标本和龈沟液标本,采用实时PCR技术对龈下菌斑内的牙龈卟啉单孢菌(Pg)、伴放线放线杆菌(Aa)、中间普氏菌(Pi)、齿密螺旋体(Td)和福赛氏类杆菌(Tf)进行定量检测,使用ELISA法测量龈沟液中白介素-1β的含量,比较牙龈增生组和对照组各项指标间的差异.对牙龈增生组患者实施牙周基础治疗,并于4周后重新采样比较牙周治疗前后上述指标间的差异.结果 基线时,牙龈增生组中龈下菌斑内五种牙周可疑微生物的检出率均显著高于对照组(P<0.05),龈沟液内白介素-1β的含量显著高于对照组(P<0.05).牙周基础治疗后4周时,牙龈增生患者的各项牙周检查指标均明显下降,同时Pg、Aa和Td的检出率、细菌数量以及龈沟液内白介素-1β的含量均显著减少(P<0.05).结论 Pg、Aa和Td等牙周病原菌和白介素-1β与正畸治疗中牙龈增生的发生和发展密切相关.
目的 探討正畸治療中牙齦增生的相關緻病因素.方法 12例因接受固定正畸治療而齣現牙齦增生的患者納入牙齦增生組,對照組為12例牙齦健康者.分彆于基線時採集兩組研究對象的牙週檢查指標、齦下菌斑標本和齦溝液標本,採用實時PCR技術對齦下菌斑內的牙齦卟啉單孢菌(Pg)、伴放線放線桿菌(Aa)、中間普氏菌(Pi)、齒密螺鏇體(Td)和福賽氏類桿菌(Tf)進行定量檢測,使用ELISA法測量齦溝液中白介素-1β的含量,比較牙齦增生組和對照組各項指標間的差異.對牙齦增生組患者實施牙週基礎治療,併于4週後重新採樣比較牙週治療前後上述指標間的差異.結果 基線時,牙齦增生組中齦下菌斑內五種牙週可疑微生物的檢齣率均顯著高于對照組(P<0.05),齦溝液內白介素-1β的含量顯著高于對照組(P<0.05).牙週基礎治療後4週時,牙齦增生患者的各項牙週檢查指標均明顯下降,同時Pg、Aa和Td的檢齣率、細菌數量以及齦溝液內白介素-1β的含量均顯著減少(P<0.05).結論 Pg、Aa和Td等牙週病原菌和白介素-1β與正畸治療中牙齦增生的髮生和髮展密切相關.
목적 탐토정기치료중아간증생적상관치병인소.방법 12례인접수고정정기치료이출현아간증생적환자납입아간증생조,대조조위12례아간건강자.분별우기선시채집량조연구대상적아주검사지표、간하균반표본화간구액표본,채용실시PCR기술대간하균반내적아간계람단포균(Pg)、반방선방선간균(Aa)、중간보씨균(Pi)、치밀라선체(Td)화복새씨류간균(Tf)진행정량검측,사용ELISA법측량간구액중백개소-1β적함량,비교아간증생조화대조조각항지표간적차이.대아간증생조환자실시아주기출치료,병우4주후중신채양비교아주치료전후상술지표간적차이.결과 기선시,아간증생조중간하균반내오충아주가의미생물적검출솔균현저고우대조조(P<0.05),간구액내백개소-1β적함량현저고우대조조(P<0.05).아주기출치료후4주시,아간증생환자적각항아주검사지표균명현하강,동시Pg、Aa화Td적검출솔、세균수량이급간구액내백개소-1β적함량균현저감소(P<0.05).결론 Pg、Aa화Td등아주병원균화백개소-1β여정기치료중아간증생적발생화발전밀절상관.
Objective To investigate the pathogenesis of gingival enlargement (GE) in orthodontic treatment. Methods The study sample included 12 patients with GE undergoing fixed orthodontic treatment and 12 periodontally healthy controls. At baseline, periodontal variables,subgingival plaque samples and gingival cervical fluid (GCF) samples were taken from two pre-selected sites in both the GE group and control group. The levels of Porphyromonas gingivalis (Pg),Aggregatibacter actinomycetemcomitans (Aa), Prevotella intermedia (Pi), Treponema denticola (Td) and Tannerella forsythensis (Tf) were determined by real-time PCR. GCF interleukin (IL)-1β were detected by ELISA. Periodontal therapy was administered to the patients in the GE group and all the parameters were reassessed after 4 weeks. Results At baseline, the GE group showed higher prevalence of five periodontal pathogens than the control group (P<0. 05). IL-1β levels at the GE sites were also significantly higher than those at the control sites (P< 0. 05). Four weeks after periodontal therapy, the GE group showed significant improvements in the clinical parameters associated with significant reductions of Pg, Aa and Td. The levels of IL-1β also decreased significantly compared with baseline (P<0. 05). Conclusions Periodontal pathogens and IL-1β may be related to the initiation and development of GE in orthodontic treatment.