CAJ | 학술논문

目的评价定期龈上洁治和龈下刮治对2型糖尿病患者牙周健康及龈沟液白介素6水平的影响.方法采用随机、对照、盲法设计,将37例2型糖尿病伴牙周炎患者分为基础治疗组(牙周基础治疗)13例、龈上洁治组(龈上洁治)11例及空白对照组13例,比较其治疗后6周、3个月和6个月时临床指标包括探诊深度(PD),附着丧失(AL),改良出血指数(mBI),菌斑指数(PLI)、龈沟液(GCF)量及龈沟液IL6水平的变化.结果基础治疗组各项指标在各时间点均较基线显著降低(P＜0.05),龈上洁治组呈现下降趋势,其中3个月时PD减少有统计学意义(⊿=0.36 mm,P＜0.05).基础治疗组、龈上洁治组6个月时GCF减少量显著高于对照组增加(0.96 μl＞0.03 μl mm＞-0.02 μl,P＜0.05).结论定期牙周机械治疗可改善糖尿病患者牙周健康及龈沟液IL-6水平.
목적 평개정기간상길치화간하괄치대2형당뇨병환자아주건강급간구액백개소6수평적영향.방법 채용수궤、대조、맹법설계,장37례2형당뇨병반아주염환자분위기출치료조(아주기출치료)13례、간상길치조(간상길치)11례급공백대조조13례,비교기치료후6주、3개월화6개월시림상지표포괄탐진심도(PD),부착상실(AL),개량출혈지수(mBI),균반지수(PLI)、간구액(GCF)량급간구액IL6수평적변화.결과 기출치료조각항지표재각시간점균교기선현저강저(P＜0.05),간상길치조정현하강추세,기중3개월시PD감소유통계학의의(⊿=0.36 mm,P＜0.05).기출치료조、간상길치조6개월시GCF감소량현저고우대조조증가(0.96 μl＞0.03 μl mm＞-0.02 μl,P＜0.05).결론 정기아주궤계치료가개선당뇨병환자아주건강급간구액IL-6수평.
Objective To evaluate the effectiveness of periodontal mechanical therapy on periodontal health and interleukin-6 (IL-6) levels in gingival crevicular fluid (GCF) in type 2 diabetic patients with chronic periodontitis. Methods GCF samples were obtained with filter papers in first molar sites from 37 type 2 diabetic patients with chronic periodontitis. The randomized controlled and blinded clinical trial with a duration of six months was designed to compare effects between three groups of professional mechanical tooth cleaning (PMTC), i.e. coronal scaling (group Ⅱ) with periodontal initial therapy (group Ⅰ) and without clinical therapy (control group). The clinical periodontal index such as probing depth (PD), attachment loss (AL), modified bleeding index (mBI) and bacteria plaque index (PLI) were obtained with a Williams type periodontal probe. Laboratory examination including GCF volume, concentrations and total amounts of IL-6 in GCF were detected with ELISA method. Results Significantly decreasing trends of PD, AL, mBI, GCF volume and total amounts of IL-6 were observed in group Ⅰin all test period. The group Ⅱ had a significant reduction of PD at the third month as compared with baseline (⊿=0.36 mm, P＜0.05), and the other figures showed descending trends but didn′t present statistical significances. At the end of study, the group Ⅰand Ⅱ had significant reductions of GCF volume compared with increases of control group (0.96 μ1＞0.03 μ1mm＞-0.20 μ1, P＜0.05). Conclusions The sequential periodontal supra- and sub- gingival scaling has definitive effects on periodontal health improvement and on reducing the IL-6 level in GCF in type 2 diabetic patients.