CAJ | 학술논문

目的探讨侵犯颅底及颌面部骨巨细胞瘤的诊断与手术治疗. 方法对川北医学院附属医院神经外科自2001年3月至2009年4月收治的3例侵犯颅底及颌面部骨巨细胞瘤患者的临床资料进行回顾性分析,总结该病的诊断要点、鉴别诊断及手术治疗体会.3例患者肿瘤均位于中颅窝底,向外侵及颌面部,临床症状以颅神经症状和面容改变为主.CT及MRI提示病变呈膨胀、破坏性生长.3例患者均行手术治疗,2例患者术后行放射治疗. 结果 3例患者术后效果良好,术后病理证实均为骨巨细胞瘤.随访中1例患者肿瘤复发但生长缓慢,另一例未见明显复发. 结论侵犯颅底及颌面部骨巨细胞瘤的诊断可根据其生长特点、其引起的颅神经症状及影像学特征来做出判断.手术是其治疗的首选方式,术后是否放疗仍存在争议.
목적 탐토침범로저급합면부골거세포류적진단여수술치료. 방법 대천북의학원부속의원신경외과자2001년3월지2009년4월수치적3례침범로저급합면부골거세포류환자적림상자료진행회고성분석,총결해병적진단요점、감별진단급수술치료체회.3례환자종류균위우중로와저,향외침급합면부,림상증상이로신경증상화면용개변위주.CT급MRI제시병변정팽창、파배성생장.3례환자균행수술치료,2례환자술후행방사치료. 결과 3례환자술후효과량호,술후병리증실균위골거세포류.수방중1례환자종류복발단생장완만,령일례미견명현복발. 결론 침범로저급합면부골거세포류적진단가근거기생장특점、기인기적로신경증상급영상학특정래주출판단.수술시기치료적수선방식,술후시부방료잉존재쟁의.
Objective To explore the diagnosis and operative therapy of giant cell tumor of bone invading base of skull and maxillofacial region. Methods We retrospectively analyzed the clinical data of 3 patients with giant cell tunlor of bone invading base of skull and maxillofacial region and summarized the key to diagnosis,differential diagnosis and operative experience of this disease.The tumors were located at the bottom of the middle cranial fossa and outwards invaded the maxillofacial region with cranial nerve signs and alteration of facial features as their clinical symptoms.Dilatation and destructive growth in the pathological region was showed by CT and MRI.Operative therapy was performed in all of the 3 patients and radiation therapy was performed in 2 after the operative therapy.Results Improvement was achieved in 3 and the tumor was confirmed to be giant cell tumor of bone by pathology.Follow-up showed 1 recurrence with slow growth and 1 with no obvious recurrence.Conclusion The diagnosis of giant cell tumor of bone invading base of skull and maxillofacial region can be made through analyzing its growth characteristic, cranial nerve sign and its imaging features.Operation is the first option and radiotherapy is still under discussion for giant cell tumor of bone.