CAJ | 학술논문

目的探讨高压氧减轻脑组织间隙水肿的作用机制。方法采用激光多谱勒和电镜方法，测量沙土鼠软脑膜微血管管径和观察脑微血管超微结构的变化。结果脑缺血30min再灌注，脑微动、静脉明显扩张，同时，血管周隙严重水肿。脑缺血的沙土鼠在高压氧（0.2MPaO2）下暴露30min，微动脉收缩，微静脉无明显变化，血管周隙水肿消退。结论在高压氧状况下，脑微动脉收缩，毛细血管内血压下降，有利于组织液吸收，从而起到减轻组织间隙水肿的作用。
목적 탐토고압양감경뇌조직간극수종적작용궤제。방법 채용격광다보륵화전경방법，측량사토서연뇌막미혈관관경화관찰뇌미혈관초미결구적변화。결과 뇌결혈30min재관주，뇌미동、정맥명현확장，동시，혈관주극엄중수종。뇌결혈적사토서재고압양（0.2MPaO2）하폭로30min，미동맥수축，미정맥무명현변화，혈관주극수종소퇴。결론 재고압양상황하，뇌미동맥수축，모세혈관내혈압하강，유리우조직액흡수，종이기도감경조직간극수종적작용。
Objective To study the mechanism of alleviating intercerebraledema in cerebral-ischemic gerbils by hyperbaric oxygen. Methods The diameters of microvessels of gerbil's pia mater were measured with laser Doppler and the ultrastructure of microvessels of gerbil's cortex was observed under electron microscope. Results The microarteries and the microveins were obviously dilated when reperfused after 30 min cerebral ischemia, and meanwhile the edema was severe around the microvessels. After the ishemic-reperfused gerbils were exposed to 0.2 Mpa O2 for 30 min, the cerebral microarteries contracted but no changes could be found in the microvein and the edema around the microvessels resolved. Conclusion During hyperbaric oxygen exposure, the cerebral microarteries contract and the capillary pressure decreases, thus favorate the absorption of tissue fluid and alleviate the intercerebral edema.