CAJ | 학술논문

目的: 探讨ω-3脂肪酸对脓毒症病人的免疫调节和抗炎作用.方法: 将18例病人随机分为鱼油治疗组和常规治疗组.鱼油治疗组病人为常规治疗加鱼油,并于治疗前和治疗后第5天用流式细胞仪检测单核细胞HLA-DR表达率,同时检测炎症反应指标,包括C反应蛋白(CRP)、IL-6和肿瘤坏死因子α(TNF-α),观察病情严重程度(APACHE Ⅱ评分)和氧合指数(PaO2/FiO2)的变化.结果: 相对于常规治疗组,鱼油治疗组病人血清CRP、IL-6和TNF-α均明显下降;氧合指数改善;单核细胞HLA-DR表达率、APACHEⅡ评分较常规治疗组无显著性差异.结论: 应用ω-3脂肪酸可使脓毒症病人血清炎症介质表达减少,但对单核细胞HLA-DR的表达未见调节作用.
목적: 탐토ω-3지방산대농독증병인적면역조절화항염작용.방법: 장18례병인수궤분위어유치료조화상규치료조.어유치료조병인위상규치료가어유,병우치료전화치료후제5천용류식세포의검측단핵세포HLA-DR표체솔,동시검측염증반응지표,포괄C반응단백(CRP)、IL-6화종류배사인자α(TNF-α),관찰병정엄중정도(APACHE Ⅱ평분)화양합지수(PaO2/FiO2)적변화.결과: 상대우상규치료조,어유치료조병인혈청CRP、IL-6화TNF-α균명현하강;양합지수개선;단핵세포HLA-DR표체솔、APACHEⅡ평분교상규치료조무현저성차이.결론: 응용ω-3지방산가사농독증병인혈청염증개질표체감소,단대단핵세포HLA-DR적표체미견조절작용.
Objective: To investigate the immune regulation mechanism and anti-inflammatory effect of ω-3 fatty acids on sepsis patients.Methods: Totle 18 patients were divided into two groups,therapy group and control group. The control group was given routine therapy while the theray group was given routine therapy and fish oil.The expression of HLA-DR on peripheral monocytes was measured by flow cytometry at the beginning and 5 d during therapy, in parallel with serum c-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and severity of the disease(APACHE Ⅱ score),serum and oxygenation index(PaO2/FiO2)Results: Compared with conventional group,serum concentration of CRP, IL-6 and TNF-α in patients of therapy group were significantly reduced,and oxygenation index improved. There was no difference in the expression of HLA-DR and APACHE Ⅱscore between two groups.Conclusion:Fish oil can decrease the elevated mediators of inflammation on sepsis patients,and can't regulation the expression of HLA-DR on peripheral monocytes.