CAJ | 학술논문

目的探讨血流剪切力对兔早期动脉粥样硬化的影响及其变化规律.方法将60只新西兰大白兔随机分为2组,对照组15只,正常饮食;实验组45只,高脂饮食.各分为3个亚组分别喂养至4、8、12周测量血流剪切力等参数,同期行血脂、血黏度及病理检查.结果实验组兔血脂各项指标显著升高;血液黏稠度随造模时间延长明显升高.同一时间点,与对照组比较,实验组血管内径均有统计学意义(P<0.01),收缩期峰值流速及剪切力在12周,舒张期峰值流速及剪切力在4周、8周有统计学意义(P<0.01).结论血流剪切力在早期动脉粥样硬化形成中具有重要作用,舒张期血流力学的改变是动脉粥样硬化形成的重要环节.
목적 탐토혈류전절력대토조기동맥죽양경화적영향급기변화규률.방법 장60지신서란대백토수궤분위2조,대조조15지,정상음식;실험조45지,고지음식.각분위3개아조분별위양지4、8、12주측량혈류전절력등삼수,동기행혈지、혈점도급병리검사.결과 실험조토혈지각항지표현저승고;혈액점주도수조모시간연장명현승고.동일시간점,여대조조비교,실험조혈관내경균유통계학의의(P<0.01),수축기봉치류속급전절력재12주,서장기봉치류속급전절력재4주、8주유통계학의의(P<0.01).결론 혈류전절력재조기동맥죽양경화형성중구유중요작용,서장기혈류역학적개변시동맥죽양경화형성적중요배절.
Objective To observe the effect of blood shearing stress on the early stage of atherosclerosis and its changing regularity.Methods 60 white New Zealand rabbits were divided into two groups randomly:15 rabbits(control group)were normal fed,while 45 rabbits(experiment group)were fed with high cholesterol diet.Each group was divided into three subgroups that were fed for 4 weeks,8 weeks and 12 weeks respectively.Blood shearing and viscosity parameters,blood lipid levels and pathological examination were proceeded at each time-point.Results The blood lipid levels of the experiment group all increased significantly and the blood viscosity increased along with the time.Compare with the control group at the same time-poind,the vessle diameter increased and the changes were significant in statistics(P<0.01).The systolic peak velocity and shearing stress were statistically different at the 12~th week,while the diastolic peak velocity and shearing stress were stastistic different at the 4~(th) and 8~(th) week.Conclusions The blood shearing stress shows important effect on the early stage of arterosclerosis,and the changes of diastolic hemodynamic changes are important.