国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2012年
10期
882-885
,共4页
张立泽%乔翠霞%薛辉%刘鹏林%赵刚
張立澤%喬翠霞%薛輝%劉鵬林%趙剛
장립택%교취하%설휘%류붕림%조강
溃愈散%溃疡性结肠炎%白细胞介素6%白细胞介素8
潰愈散%潰瘍性結腸炎%白細胞介素6%白細胞介素8
궤유산%궤양성결장염%백세포개소6%백세포개소8
Kuiyu dection%Ulcerative colitis%IL-6%IL-8
目的 探讨溃愈散治疗溃疡性结肠炎(ulcerative colitis,UC)的临床疗效及其作用机制.方法 将120例溃疡性结肠炎患者按照完全随机方法分为两组各60例,治疗组采用溃愈散保留灌肠治疗,1次/d;对照组口服柳氮磺胺吡啶片,1g/次,3次/d,两组患者均治疗15d为1个疗程,间隔后7d进行下个疗程,3个疗程后比较两组患者的临床综合疗效、主要症状、结肠镜镜检积分改善情况,以及治疗前后患者血清白细胞介素6 (IL-6)、白细胞介素8(IL-8)的水平变化,治疗后对两组完全缓解及有效病例随防6个月,观察其复发率.结果 治疗组总有效率为93.33％,优于对照组78.33％(x2=9.027,P＜0.05);治疗后治疗组较对照组在腹泻、脓血便的改善上更为明显(x2值分别为5.630、5.972,P＜0.05),能明显降低UC患者血清IL-6、IL-8的水平(x2=8.314,P＜0.01);结肠镜镜检积分显示两组治疗后充血、糜烂、溃疡均有明显改善,治疗组优于对照组(x2=8.322,P＜ 0.05);随访6个月,治疗组复发率低于对照组,差异有统计学意义(x2=5.857,P＜0.05).结论 溃愈散通过下调IL-6、IL-8水平治疗溃疡性结肠炎,缓解率高、安全性好.
目的 探討潰愈散治療潰瘍性結腸炎(ulcerative colitis,UC)的臨床療效及其作用機製.方法 將120例潰瘍性結腸炎患者按照完全隨機方法分為兩組各60例,治療組採用潰愈散保留灌腸治療,1次/d;對照組口服柳氮磺胺吡啶片,1g/次,3次/d,兩組患者均治療15d為1箇療程,間隔後7d進行下箇療程,3箇療程後比較兩組患者的臨床綜閤療效、主要癥狀、結腸鏡鏡檢積分改善情況,以及治療前後患者血清白細胞介素6 (IL-6)、白細胞介素8(IL-8)的水平變化,治療後對兩組完全緩解及有效病例隨防6箇月,觀察其複髮率.結果 治療組總有效率為93.33％,優于對照組78.33％(x2=9.027,P＜0.05);治療後治療組較對照組在腹瀉、膿血便的改善上更為明顯(x2值分彆為5.630、5.972,P＜0.05),能明顯降低UC患者血清IL-6、IL-8的水平(x2=8.314,P＜0.01);結腸鏡鏡檢積分顯示兩組治療後充血、糜爛、潰瘍均有明顯改善,治療組優于對照組(x2=8.322,P＜ 0.05);隨訪6箇月,治療組複髮率低于對照組,差異有統計學意義(x2=5.857,P＜0.05).結論 潰愈散通過下調IL-6、IL-8水平治療潰瘍性結腸炎,緩解率高、安全性好.
목적 탐토궤유산치료궤양성결장염(ulcerative colitis,UC)적림상료효급기작용궤제.방법 장120례궤양성결장염환자안조완전수궤방법분위량조각60례,치료조채용궤유산보류관장치료,1차/d;대조조구복류담광알필정편,1g/차,3차/d,량조환자균치료15d위1개료정,간격후7d진행하개료정,3개료정후비교량조환자적림상종합료효、주요증상、결장경경검적분개선정황,이급치료전후환자혈청백세포개소6 (IL-6)、백세포개소8(IL-8)적수평변화,치료후대량조완전완해급유효병례수방6개월,관찰기복발솔.결과 치료조총유효솔위93.33％,우우대조조78.33％(x2=9.027,P＜0.05);치료후치료조교대조조재복사、농혈편적개선상경위명현(x2치분별위5.630、5.972,P＜0.05),능명현강저UC환자혈청IL-6、IL-8적수평(x2=8.314,P＜0.01);결장경경검적분현시량조치료후충혈、미란、궤양균유명현개선,치료조우우대조조(x2=8.322,P＜ 0.05);수방6개월,치료조복발솔저우대조조,차이유통계학의의(x2=5.857,P＜0.05).결론 궤유산통과하조IL-6、IL-8수평치료궤양성결장염,완해솔고、안전성호.
Objective To observe the effect of Kuiyu dection on ulcerative colitis and to explore its mechanism.Methods 120 patients with ulcerative colitis were randomly divided into a treatment group and a control group,60 cases in each group.The treatment group was treated with Kuiyu dection retention enema,1 time a day,15 days for a course of treatment; and the control group was treated with SASP orally,2 g every time,3 times a day,and 15 days for a course of treatment.All patients with a course of treatment for the next 7 days after the rest period of treatment,evaluated after 3 courses.Comprehensive clinical efficacy,the main symptoms,score of integral electronic colonoscopy examination,and the changes of IL-6,IL 8 levels were observed in both groups after treatment with complete remission and six months followed-up,besides,the recurrence rate was also observed.Results The total effective rate was 93.33％ in the treatment group,better than the control group 78.33％ (x2 =9.027,P＜0.05) ; the treatment group also showed better results in diarrhea,pus and blood improvement than the control group (x2=5.630、x2=5.972,P＜0.05),the treatment group could significantly reduce UC Serum IL-6,IL-8 level (x2=8.314,P＜0.01); electronic colonoscopy examination points,hyperemia,erosions,ulcers in both groups were significantly improved,but the treatment group was significantly better than the control group (x2=8.322,P＜0.05) ; 6 months followed-up and the recurrence rate in treatment group were better than control group,and the difference was statistically significant (x2=5.857,P＜0.05).Conclusion Through decreasing the IL-6,IL 8 levels,Kuiyu dection can treat ulcerative colitis,with significant effect,non-toxic side effects,inexpensive,and easy for use.
