CAJ | 학술논문

"慢性疾病胎儿起源学说"假说、"节俭表型假说"、"营养程序化"、"代谢程序化" 概念指出了早期营养与远期健康的关系问题,流行病学调查也已证实宫内发育迟缓与胰岛素抵抗密切相关,但宫内发育迟缓发生胰岛素抵抗的具体机制目前尚未明确.遗传信息的调控可能会不同程度改变胎儿组织器官的结构和功能,在基因水平上,胰十二指肠同源盒基因、Munc13-1、过氧化物酶体增殖物激活受体基因、胰岛素受体底物基因、线粒体DNA、ghrelin mRNA等的表达情况都对宫内发育迟缓发生胰岛素抵抗有影响.
"만성질병태인기원학설"가설、"절검표형가설"、"영양정서화"、"대사정서화" 개념지출료조기영양여원기건강적관계문제,류행병학조사야이증실궁내발육지완여이도소저항밀절상관,단궁내발육지완발생이도소저항적구체궤제목전상미명학.유전신식적조공가능회불동정도개변태인조직기관적결구화공능,재기인수평상,이십이지장동원합기인、Munc13-1、과양화물매체증식물격활수체기인、이도소수체저물기인、선립체DNA、ghrelin mRNA등적표체정황도대궁내발육지완발생이도소저항유영향.
Fetal origins of adult disease,the thrifty phenotype hypothesis, nutritional programming,metabolic programming indicate that nutrition in early life is important.Epidemiological survey demonstrates that insulin resistance is relataed to intrauterine growth retardation,but the exact mechanism is indefinite.This article is about the influence of intrauterine growth retardation to the structure and function of pancreas,and the genes that related to insulin resistance.