CAJ | 학술논문

目的观察香菇多糖注射液联合鸦胆子油乳注射液姑息性治疗晚期消化道恶性肿瘤的近期临床疗效.方法回顾性分析42例晚期消化道恶性肿瘤患者的临床资料,根据治疗方法不同分为对照组和治疗组,每组21例,对照组单纯应用鸦胆子油乳治疗；治疗组予以香菇多糖注射液联合鸦胆子油乳治疗.3周期后观察两组患者的疗效、生存质量(QOL)评分和不良反应.结果治疗组与对照组治疗后生存质量改善率分别为81.0％( 17/21)与47.6％( 10/21),差异有统计学意义(x2=5.081,P=0.024).治疗组与对照组客观缓解率分别为19.0％ (4/21)和14.3％ (3/21),差异无统计学意义(x2=0.171,P=0.679),疾病控制率分别为85.7％( 18/21)和61.9％( 12/21),差异有统计学意义(x2=4.200,P =0.040).两组肝肾功能、消化道不良反应及皮肤瘙痒不良反应发生率比较差异无统计学意义(P＞0.05).治疗组静脉炎发生率明显低于对照组,两组比较有统计学意义(P＜0.05).结论香菇多糖注射液联合鸦胆子油乳姑息性治疗晚期消化道恶性肿瘤能提高疗效,明显改善患者生存质量,且安全有效.
목적 관찰향고다당주사액연합아담자유유주사액고식성치료만기소화도악성종류적근기림상료효.방법 회고성분석42례만기소화도악성종류환자적림상자료,근거치료방법불동분위대조조화치료조,매조21례,대조조단순응용아담자유유치료；치료조여이향고다당주사액연합아담자유유치료.3주기후관찰량조환자적료효、생존질량(QOL)평분화불량반응.결과 치료조여대조조치료후생존질량개선솔분별위81.0％( 17/21)여47.6％( 10/21),차이유통계학의의(x2=5.081,P=0.024).치료조여대조조객관완해솔분별위19.0％ (4/21)화14.3％ (3/21),차이무통계학의의(x2=0.171,P=0.679),질병공제솔분별위85.7％( 18/21)화61.9％( 12/21),차이유통계학의의(x2=4.200,P =0.040).량조간신공능、소화도불량반응급피부소양불량반응발생솔비교차이무통계학의의(P＞0.05).치료조정맥염발생솔명현저우대조조,량조비교유통계학의의(P＜0.05).결론 향고다당주사액연합아담자유유고식성치료만기소화도악성종류능제고료효,명현개선환자생존질량,차안전유효.
Objective To study the short-term clinical efficacy of treating patients with advanced gastrointestinal cancer with lentinan injection and javanica oil emulsion injection.Methods Clinical information of 42 patients with advanced gastrointestinal cancer were retrospectively collected.The 42 patients were divided into two groups according to treatments,with 21 case in the control group who were treated with javanica oil emulsion injection,as well as 21 case in the treatment group treated with lentinan injection and javanica oil emulsion injection.The efficacy,quality of life (QOL) and adverse effects were observed after treatment for 3 weeks.Results 81.0％ (17/21)of patients in the treatment group improved in QOL,which was much higher than that in the control group 47.6％ ( 10/21 ) ( x2 =5.081,P =0.024 ).The objective remission rate was 19.0％ (4/21)and 14.3％ (3/21)in the treatment group and the control group respectively,with no significant differece bwtween the two groups( x2 =0.171,P =0.679 ).the disease control rate was 85.7％ (18/21)in the treatment group,which was significantly higher than that of 61.9％ (12/21)in the control group( x2 =4.200,P =0.040 ).The incidence of adverse effect related to hematological toxicity,liver and kidney function,the digestive tract and itching of skin were similar between the two groups (Ps ＞ 0.05 ).Phlebitis in the treatment group was not as frequent as that in the control group(P ＜0.05).Conclusion Treating patients with advanced gastrointestinal cancer with lentinan injection and javanica oil emulsion injection had high efficacy than treating only with javanica oil emulsion injection,and it improved QOL signifiantly with safety.