中华外科杂志
中華外科雜誌
중화외과잡지
CHINESE JOURNAL OF SURGERY
2008年
24期
1906-1909
,共4页
吴国豪%曹冬兴%魏嘉%全应军%吴肇汉
吳國豪%曹鼕興%魏嘉%全應軍%吳肇漢
오국호%조동흥%위가%전응군%오조한
肿瘤%营养牛理学%能量代澍%物质代谢
腫瘤%營養牛理學%能量代澍%物質代謝
종류%영양우이학%능량대주%물질대사
Neoplasms%Nutrition physiology%Energy metabolism%Substance metabolism
目的 评价恶性肿瘤患者能量消耗、物质代谢和机体组成变化.方法 2004年9月至2008年3月应用间接测热法测定936例恶性肿瘤患者和840例非恶性肿瘤患者静息能量消耗、碳水化合物及脂肪氧化率;应用生物电阻抗法测定所有研究对象机体总体水、细胞外液、细胞内液、体脂及瘦组织群含量.结果 恶性肿瘤患者静息能最消耗测定值与对照组差异无统计学意义[(1452.2±196.4)kcal/d vs(1429.5±182.6)kcal/d,P=0.136],但经瘦组织群和预测公式矫正后存在明显差异(P均<0.05).恶性肿瘤患者中48.6%为高代谢,42.9%为正常代谢,8.5%为低代谢,对照组则分别为22.5%、58.5%、19.0%.恶性肿瘤组脂肪氧化率高于对照组[(77.8±11.3)g/min vs.(67.1±12.2)g,/win,P=0.000],碳水化合物氧化率及非蛋白呼吸商低于对照组[(68.7±10.5)g/min眠(88.8±12.1)g/min,P=0.000;0.782±0.012 vs.0.810±0.014,P=0.000].恶性肿瘤患者体脂及瘦组织群含昔低于对照组[(14.9±4.5)kg vs.(18.4±5.2)kg,P=0.000;(44.4±7.2)kg vs.(46.1±8.1)kg,P=0.008].结论 恶性肿瘤患者总体上处于高代谢状态,脂肪氧化增加,碳水化合物氧化降低,体脂、瘦组织群及细胞总体丢失.
目的 評價噁性腫瘤患者能量消耗、物質代謝和機體組成變化.方法 2004年9月至2008年3月應用間接測熱法測定936例噁性腫瘤患者和840例非噁性腫瘤患者靜息能量消耗、碳水化閤物及脂肪氧化率;應用生物電阻抗法測定所有研究對象機體總體水、細胞外液、細胞內液、體脂及瘦組織群含量.結果 噁性腫瘤患者靜息能最消耗測定值與對照組差異無統計學意義[(1452.2±196.4)kcal/d vs(1429.5±182.6)kcal/d,P=0.136],但經瘦組織群和預測公式矯正後存在明顯差異(P均<0.05).噁性腫瘤患者中48.6%為高代謝,42.9%為正常代謝,8.5%為低代謝,對照組則分彆為22.5%、58.5%、19.0%.噁性腫瘤組脂肪氧化率高于對照組[(77.8±11.3)g/min vs.(67.1±12.2)g,/win,P=0.000],碳水化閤物氧化率及非蛋白呼吸商低于對照組[(68.7±10.5)g/min眠(88.8±12.1)g/min,P=0.000;0.782±0.012 vs.0.810±0.014,P=0.000].噁性腫瘤患者體脂及瘦組織群含昔低于對照組[(14.9±4.5)kg vs.(18.4±5.2)kg,P=0.000;(44.4±7.2)kg vs.(46.1±8.1)kg,P=0.008].結論 噁性腫瘤患者總體上處于高代謝狀態,脂肪氧化增加,碳水化閤物氧化降低,體脂、瘦組織群及細胞總體丟失.
목적 평개악성종류환자능량소모、물질대사화궤체조성변화.방법 2004년9월지2008년3월응용간접측열법측정936례악성종류환자화840례비악성종류환자정식능량소모、탄수화합물급지방양화솔;응용생물전조항법측정소유연구대상궤체총체수、세포외액、세포내액、체지급수조직군함량.결과 악성종류환자정식능최소모측정치여대조조차이무통계학의의[(1452.2±196.4)kcal/d vs(1429.5±182.6)kcal/d,P=0.136],단경수조직군화예측공식교정후존재명현차이(P균<0.05).악성종류환자중48.6%위고대사,42.9%위정상대사,8.5%위저대사,대조조칙분별위22.5%、58.5%、19.0%.악성종류조지방양화솔고우대조조[(77.8±11.3)g/min vs.(67.1±12.2)g,/win,P=0.000],탄수화합물양화솔급비단백호흡상저우대조조[(68.7±10.5)g/min면(88.8±12.1)g/min,P=0.000;0.782±0.012 vs.0.810±0.014,P=0.000].악성종류환자체지급수조직군함석저우대조조[(14.9±4.5)kg vs.(18.4±5.2)kg,P=0.000;(44.4±7.2)kg vs.(46.1±8.1)kg,P=0.008].결론 악성종류환자총체상처우고대사상태,지방양화증가,탄수화합물양화강저,체지、수조직군급세포총체주실.
Objective To demonstrate the changes of resting energy expenditure( REE), substrate metabolism and body composition in cancer patients. Methods From September 2004 to March 2008, REE, carbohydrate oxidation(CO) and fat oxidation (FO) in 936 cancer patients and 840 control subjects were measured by indirect calorimetry.Bioelectrical impedance appliance was applied to assess intracellular fluid, extracellular fluid, fat mass (FM) and fat free mass (FFM) in the two groups. Results No difference in REE was found between the cancer patients and non-cancer patients [ ( 1452.2±196.4) kcal/ d vs. ( 1429.5±182.6) kcal/d,P =0.136].But REE/FFM and REE/pREE were elevated in cancer patients than in controls ( all P <0.05 ).Of the cancer patients, 48.6% were hypermetabolic, 42.9% normal and 8.5% hypometabolic, while those were 22.5%, 58.5% and 19.0% in controls. Cancer patients had higher FO [ (77.8±11.3 ) g/rain vs.(67.1±12.1 ) g/min, P = 0.000 ], lower CO and npRQ [(68.7±10.5)g/min vs.(88.8 ～12.1)g/rain, P=0.000;0.782 ～0.012 vs.0.810 +0.014, P= 0.000].Cancer patients exhibited lower FM and FFM [ ( 14.9±4.5) kg vs.( 18.4±5.2) kg, P =0.000;(44.4±7.2) kg vs. (46.1±8.1 ) kg, P =0.008 ].Conclusions Elevated REE is common in cancer patients.Substrate metabolism of the cancer patients features in increased FO, decreased CO and npRQ, which is correlated with the elevated REE.FM and FFM loses in proportion in cancer patients.
