中华烧伤杂志
中華燒傷雜誌
중화소상잡지
16
2012年
1期
78-80
,共3页
张振宇%陈俊杰%于蓉%岑瑛
張振宇%陳俊傑%于蓉%岑瑛
장진우%진준걸%우용%잠영
热休克蛋白质类%瘢痕疙瘩%NF-κB%热休克因子
熱休剋蛋白質類%瘢痕疙瘩%NF-κB%熱休剋因子
열휴극단백질류%반흔흘탑%NF-κB%열휴극인자
Heat-shock proteins%Keloid%NF-κB%Heat-shock factor
This article reviews the advances in the research of the structural characteristics and the activating process of heat shock factor 1(HSF-1),the factors that influence the expression of HSF-1,and the relationship between HSF-1 and the expression levels of NF-κB and heat shock protein(HSP).The expression of HSF-1 could be regulated in several stages in the course of interconversion between its active and inactive status.Unusual expression of HSF-1 mediated by NF-κB can lead to the quantitive and functional change of HSP.The quantifive and functional variation of HSP caused by regulation of HSF-1 could influence the normal synthesis and the pathological changes induced by excessive synthesis of protective proteins in cells under stress.We expect that further research would help elucidate novel pathways about the genesis and evolution mechanism of keloid,and it may finally help to find a novel strategy in the treatment of keloid.
