CAJ | 학술논문

目的分析中国北方汉族人群非酒精性血清ALT水平升高与各代谢参数的相关性.方法将5351名在清华大学玉泉医院体检的受试者根据ALT升高与否(≥40 U/L)分为两组,比较两组间各代谢组分的差异.结果体重指数(BMI)、收缩压、舒张压、甘油三酯、总胆固醇、高密度脂蛋白胆同醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及空腹血糖(FBG)水平在ALT升高组与对照组间差异有统计学意义.男性ALT升高与舒张压有关,而女性与收缩压有关.logistic回归分析结果表明,ALT升高与男性、BMI、甘油三酯、总胆固醇和FBG水平升高、LDL-C水平降低和年龄较低有关.结论在中国北方汉族人群中,肥胖、高血压、高血脂、高血糖等代谢紊乱与非酒精性ALT升高有关.
목적 분석중국북방한족인군비주정성혈청ALT수평승고여각대사삼수적상관성.방법 장5351명재청화대학옥천의원체검적수시자근거ALT승고여부(≥40 U/L)분위량조,비교량조간각대사조분적차이.결과 체중지수(BMI)、수축압、서장압、감유삼지、총담고순、고밀도지단백담동순(HDL-C)、저밀도지단백담고순(LDL-C)급공복혈당(FBG)수평재ALT승고조여대조조간차이유통계학의의.남성ALT승고여서장압유관,이녀성여수축압유관.logistic회귀분석결과표명,ALT승고여남성、BMI、감유삼지、총담고순화FBG수평승고、LDL-C수평강저화년령교저유관.결론 재중국북방한족인군중,비반、고혈압、고혈지、고혈당등대사문란여비주정성ALT승고유관.
Objective The aim of this study is to identify association between increased serum activity of alanine aminotransferase (ALT) and metabolic parameters in non-alcoholic population of north China. Methods A total of 5351 subjects who came to visit Yuquan Hospital of Tsinghua University for health examinations during May to December 2007 were divided into two groups based on their serum ALT activities, one with equal to or more than 40 U/L and the other with less than 40. Anthropometric data, blood pressure, serum ALT, serum levels of triglyceride (TG), total cholesterol (TC), high-dense lipoprotein-cholesterol (HDL-C), low-dense lipoprotein-cbolesterol (LDL-C) and fasting blood glucose (FBG) were measured for all of them. Results Body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), TG, TC, HDL-C, LDL-C and FBG were significantly different between the two groups. BMI, TG, TC, HDL-C, LDL-C and FBG all associated with increased ALT both in males and females. DBP associated with increased ALT in males and SBP with it in females, logistic regression analysis showed that male, younger age, raised BMI, TG, TC, FBG and reduced HDL-C were strongly associated with increased serum ALT. Conclusions Results showed that metabolic disturbance such as obesity, hypertension, dyalipidemia, hyperglycemia, and so on associated with increased ALT in non-alcoholic population of north China.