CAJ | 학술논문

目的探讨原发于眼睑皮肤黑色素瘤的临床、病理及免疫组化特点.方法回顾中山眼科中心1963年7月到2008年3月收治的12例眼睑皮肤恶性黑色素瘤患者临床资料,观察其临床病理特点并进行免疫组化分析.结果眼睑皮肤黑色素瘤发病多发生于上睑,发病年龄平均在56.42岁,发病无性别、眼别差异.组织病理学以水平扩散型多见(7例,58.3%),其次为结节型(4例,333%),恶性雀斑(1例,8.3%).按细胞形态分型以上皮样细胞型多见,其次为混合细胞型和梭形细胞型.Breslow厚度平均1.73mm.临床分期以Ⅰ期多见.免疫组化HMB45,S-100染色均呈阳性表达.有随访资料的3例患者中2例于术后1年内死亡.结论眼睑皮肤恶性黑色素瘤是一种预后较差的恶性肿瘤,肿瘤厚度和有丝分裂指数可作为预后相关指标.免疫组化HMB45、S-100染色有助于诊断.
목적 탐토원발우안검피부흑색소류적림상、병리급면역조화특점.방법 회고중산안과중심1963년7월도2008년3월수치적12례안검피부악성흑색소류환자림상자료,관찰기림상병리특점병진행면역조화분석.결과 안검피부흑색소류발병다발생우상검,발병년령평균재56.42세,발병무성별、안별차이.조직병이학이수평확산형다견(7례,58.3%),기차위결절형(4례,333%),악성작반(1례,8.3%).안세포형태분형이상피양세포형다견,기차위혼합세포형화사형세포형.Breslow후도평균1.73mm.림상분기이Ⅰ기다견.면역조화HMB45,S-100염색균정양성표체.유수방자료적3례환자중2례우술후1년내사망.결론 안검피부악성흑색소류시일충예후교차적악성종류,종류후도화유사분렬지수가작위예후상관지표.면역조화HMB45、S-100염색유조우진단.
Objective To study the clinicopathologic and immunohistochemical features of primary malignant melanomas of eyelid skin.Methods Retrospectively study of 12 cases of malignant melanoma of eyelid skin by pathological diagnosis at Zhongshan Ophthalmic Center between July 1963 and March 2008.The clinical data and histopathologic sections were reviewed and immunohistochemical stains were performed in each case.Results The upper eyelid was more frequently the site of origin.There was no gender or side prediction.Patients ranged in age from 25 to 85 years with an average of 56.42 years.The histopathologic classification of melanomas included superficial spreading melanoma (58.3%, 7 cases), nodular melanoma (33.3%,4 cases) and lentigo maligna melanoma (8.3%, 1 case).The average Breslow thickness was 1.73mm.Immunohistochemical stains showed 12 cases (100%) were positive for S-100 and HMB45.Two of three cases with fellow-up data available died of metastatic melanoma within one year.Conclusions The prognosis of primary malignant melanoma of eyelid skin is poor.Tumor thickness, mitotic rate are the most significant powerful predictors.HMB45 and S-100 are helpful for diagnosis.