CAJ | 학술논문

目的研究表皮生长因子受体(EGFR)在宫颈癌及宫颈上皮内瘤样病变(CIN)中的表达,并探讨其与宫颈癌发生、浸润转移及预后的相互关系.方法应用免疫组化法对100例宫颈癌、60例CIN及40例正常宫颈上皮组织中的EGFR进行检测.结果正常上皮、CIN、宫颈癌组织的EGFR过表达率分别为O%(0/40)、51.67%(31/60)、78.00%(78/100).宫颈癌组的EGFR过表达率显著高于CIN组(P<0.05,OR=3.32,95%CI∶1.67～6.63),2组的EGFR过表达率均显著高于对照组(P均<0.01).EGFR过表达与宫颈癌临床分期、肿瘤体积、病理类型、组织分化、宫颈浸润深度、颈管侵犯及淋巴结转移均无显著相关(P均>0.05),与宫颈癌预后也无显著相关(P>0.05).结论在宫颈癌变过程中,EGFR过度表达水平随着宫颈病变程度的加重而上升,提示EGFR过度表达与宫颈肿瘤的发生相关,EGFR可能成为有价值的宫颈癌生物学指标.EGFR过度表达与宫颈癌临床病理特征及预后无关.
목적 연구표피생장인자수체(EGFR)재궁경암급궁경상피내류양병변(CIN)중적표체,병탐토기여궁경암발생、침윤전이급예후적상호관계.방법 응용면역조화법대100례궁경암、60례CIN급40례정상궁경상피조직중적EGFR진행검측.결과 정상상피、CIN、궁경암조직적EGFR과표체솔분별위O%(0/40)、51.67%(31/60)、78.00%(78/100).궁경암조적EGFR과표체솔현저고우CIN조(P<0.05,OR=3.32,95%CI∶1.67～6.63),2조적EGFR과표체솔균현저고우대조조(P균<0.01).EGFR과표체여궁경암림상분기、종류체적、병리류형、조직분화、궁경침윤심도、경관침범급림파결전이균무현저상관(P균>0.05),여궁경암예후야무현저상관(P>0.05).결론재궁경암변과정중,EGFR과도표체수평수착궁경병변정도적가중이상승,제시EGFR과도표체여궁경종류적발생상관,EGFR가능성위유개치적궁경암생물학지표.EGFR과도표체여궁경암림상병리특정급예후무관.
Objective To study the expression of epidermal growth factor receptor (EGFR) in cervical car-cinoma and cervical intraepithelial neoplasia(CIN),and to elucidate its relation with the genesis, infiltration, metas-tasis and prognosis of cervical carcinoma. Methods EGFR was determined by means of S-P immunohistochemistry in tissue of 100 cases of cervical carcinoma,60 cases of CIN and 40 cases of controls. Results The overexpression rates of EGFR were 0% (0/40), 51.67% (31/60),78.00% (78/100), respectively in normal cervical epithelium, CIN and cervical tumor tissues. The overexpression rate of EGFR was significantly higher in cervical tumor tissue than in control group(P<0.01). The overexpression of EGFR didn't demonstrate significant association with clinical staging, tumor size, pathological type, differentiation, cervical invasion depth, cervical canal invasion, lymphnode me-tastasis or the prognosis of cervical neoplasm (P>0.05). Conclusion Overexpression of EGFR is worsened with the severity of cervical lesion, suggesting that overexpression of EGFR is correlated with the genesis of cervical neo-plasms,which may be a valuable biological indicator of cervical carcinoma,but is not correlated with clinical patho-logical features and prognosis of cervical carcinoma.