中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2008年
11期
1447-1449
,共3页
糖尿病,2型/并发症%高尿酸血症/并发症%尿酸/血液%代谢综合征X
糖尿病,2型/併髮癥%高尿痠血癥/併髮癥%尿痠/血液%代謝綜閤徵X
당뇨병,2형/병발증%고뇨산혈증/병발증%뇨산/혈액%대사종합정X
Diabetes mellitus,type 2/CO%Hyporuricemia/CO%Uric acid/CO%Metabolic syndrome X
目的 分析2型糖尿病(T2DM)高尿酸血症的临床及生化特征,并探讨血尿酸(UA)与代谢综合征(MS)组分数目的 关系.结果 采用横断面研究结果 ,将547例T2DM患者按UA分为高尿酸血症组和正常尿酸组;按具有代谢综合征组分的数目不同分为4组(MS1,MS2,MS3及MS4),分析临床资料.结果 T2DM并高尿酸血症组的体重指数(BMI)、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、肌酐(Cr)、甘油三酯(TG)、总胆固醇(TC)、糖化血红蛋白(HbA1c)明显高于正常尿酸组(P<0.05.P<0.01),高密度脂蛋白胆固醇(HDL-C)明显低于正常尿酸组(P<0.05),低密度脂蛋白胆固醇(LDL-C)2组间差异无统计学意义(P>0.05);MS1-4组问UA、BMI、SBP、DBP、Cr、TG、TC、LDL-C、HDL-C差别均有统计学意义(P均<0.05),年龄、FPG差别无统计学意义;UA与性别、TG、HbA1c、HDL-C、Cr有线性回归关系(P<0.05,P<0.01),其中与HbA1c、HDL-C负相关,TG对UA影响最大.结论 随着代谢综合征组分数目的 增加,T2DM患者UA增加,异常TG对UA影响最大,因此UA水平升高是代谢综合征的危险因素.
目的 分析2型糖尿病(T2DM)高尿痠血癥的臨床及生化特徵,併探討血尿痠(UA)與代謝綜閤徵(MS)組分數目的 關繫.結果 採用橫斷麵研究結果 ,將547例T2DM患者按UA分為高尿痠血癥組和正常尿痠組;按具有代謝綜閤徵組分的數目不同分為4組(MS1,MS2,MS3及MS4),分析臨床資料.結果 T2DM併高尿痠血癥組的體重指數(BMI)、收縮壓(SBP)、舒張壓(DBP)、空腹血糖(FPG)、肌酐(Cr)、甘油三酯(TG)、總膽固醇(TC)、糖化血紅蛋白(HbA1c)明顯高于正常尿痠組(P<0.05.P<0.01),高密度脂蛋白膽固醇(HDL-C)明顯低于正常尿痠組(P<0.05),低密度脂蛋白膽固醇(LDL-C)2組間差異無統計學意義(P>0.05);MS1-4組問UA、BMI、SBP、DBP、Cr、TG、TC、LDL-C、HDL-C差彆均有統計學意義(P均<0.05),年齡、FPG差彆無統計學意義;UA與性彆、TG、HbA1c、HDL-C、Cr有線性迴歸關繫(P<0.05,P<0.01),其中與HbA1c、HDL-C負相關,TG對UA影響最大.結論 隨著代謝綜閤徵組分數目的 增加,T2DM患者UA增加,異常TG對UA影響最大,因此UA水平升高是代謝綜閤徵的危險因素.
목적 분석2형당뇨병(T2DM)고뇨산혈증적림상급생화특정,병탐토혈뇨산(UA)여대사종합정(MS)조분수목적 관계.결과 채용횡단면연구결과 ,장547례T2DM환자안UA분위고뇨산혈증조화정상뇨산조;안구유대사종합정조분적수목불동분위4조(MS1,MS2,MS3급MS4),분석림상자료.결과 T2DM병고뇨산혈증조적체중지수(BMI)、수축압(SBP)、서장압(DBP)、공복혈당(FPG)、기항(Cr)、감유삼지(TG)、총담고순(TC)、당화혈홍단백(HbA1c)명현고우정상뇨산조(P<0.05.P<0.01),고밀도지단백담고순(HDL-C)명현저우정상뇨산조(P<0.05),저밀도지단백담고순(LDL-C)2조간차이무통계학의의(P>0.05);MS1-4조문UA、BMI、SBP、DBP、Cr、TG、TC、LDL-C、HDL-C차별균유통계학의의(P균<0.05),년령、FPG차별무통계학의의;UA여성별、TG、HbA1c、HDL-C、Cr유선성회귀관계(P<0.05,P<0.01),기중여HbA1c、HDL-C부상관,TG대UA영향최대.결론 수착대사종합정조분수목적 증가,T2DM환자UA증가,이상TG대UA영향최대,인차UA수평승고시대사종합정적위험인소.
Objective To evaluate the clinical and biochemical characteristics of type 2 diabetics with hyperuricemia and to investi-gate the association between serum uric acid and the number of metabolic syndrome components. Method In the cross-sectional study of 547 type 2 diabetics, we recorded body mass index (BMI), systolic blood pressure(SBP), diastolic blood pressure (DBP), and collected blood samples to measure serum uric acid (UA), fasting plasma glucose (FPG), glycosylated hemoglobin (HbAlc), creatinine (Cr) and blood lipid profile, including tfiglyceride (TG), total cholesterol (TC), low-density cholesterol LDL-C) and high-density cholesterol (HDL-C). Results Compared with the normal UA group, the diabetic patients in the high UA group had significantly increased levels of BMI, SBP, DBP, FPG, Cr, TG, TC and HbA1c (P <0.05, P <0.01, P <0.05, P <0.01, P <0.01), and decreased level of HDL-C(P < 0.05). There was no significant difference in the level of LDL-C between the two groups (P > 0.05). According to their possession of 1, 2, 3 or 4 components of metabolic syndrome, 547 cases were divided into four groups (MSI, MS2,MS3 and MS4). There were significant difference in the levels of UA, BMI, SBP, DBP, Cr, TG, TC, LDL-C and HDL-C among MSI, MS2, MS3 and MS4 (All P < 0.05). Multiple regression analysis showed that UA concentration was positively correlated with sex, TG and Cr (Beta:0. 088,0. 350, 0. 124; P < 0.05, P <0.01, P <0.01) and negatively correlated with HDL-C and HbA1 c(Beta: -0.107, -0.124 ; P <0.01, P <0.01). The con-centration of UA was strongly correlated with serum TG. Conclusions Serum UA level in type 2 diabetics was significantly elevated as the number of metabolic components increased. Abnormal TG had great influence on serum UA. Hyperuricemia was considered to be a dangerous factor of the metabolic syndrome.
