国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2010年
2期
156-158
,共3页
葛彦虎%缪雪蓉%吴飞翔%俞卫锋
葛彥虎%繆雪蓉%吳飛翔%俞衛鋒
갈언호%무설용%오비상%유위봉
NF-κB%神经病理性疼痛%炎症反应%凋亡%突触重塑
NF-κB%神經病理性疼痛%炎癥反應%凋亡%突觸重塑
NF-κB%신경병이성동통%염증반응%조망%돌촉중소
NF- κ B%Neuropathic pain%Inflammation%Apoptosis%Synaptic plasticity
核转录因子κB(nuclear transcriptrion factor κB,NF-κB)调控着多方面的细胞功能,包括细胞增殖,细胞凋亡,细胞分化,免疫反应等.最近研究表明,NF-κB通过参与神经系统炎症反应、神经细胞凋亡、突触重塑影响神经病理性疼痛.神经病理性疼痛严重影响患者的生活质量,目前仍没有有效的治疗方法,现就近年来NF-κB与神经病理性疼痛的相关研究作一综述.
覈轉錄因子κB(nuclear transcriptrion factor κB,NF-κB)調控著多方麵的細胞功能,包括細胞增殖,細胞凋亡,細胞分化,免疫反應等.最近研究錶明,NF-κB通過參與神經繫統炎癥反應、神經細胞凋亡、突觸重塑影響神經病理性疼痛.神經病理性疼痛嚴重影響患者的生活質量,目前仍沒有有效的治療方法,現就近年來NF-κB與神經病理性疼痛的相關研究作一綜述.
핵전록인자κB(nuclear transcriptrion factor κB,NF-κB)조공착다방면적세포공능,포괄세포증식,세포조망,세포분화,면역반응등.최근연구표명,NF-κB통과삼여신경계통염증반응、신경세포조망、돌촉중소영향신경병이성동통.신경병이성동통엄중영향환자적생활질량,목전잉몰유유효적치료방법,현취근년래NF-κB여신경병이성동통적상관연구작일종술.
Nuclear transcription factor κ B (NF-κ B) almost plays a role in every aspect of cell regulation: proliferation, apoptosis,differentiation, immune activation. Recent research found that NF-κ B contributes to the development of neuropathic pain via inflammation, apoptosis and synaptic plasticity mechanisms. Neuropathic pain severely affects the quality of a patient's life, the management of neuropathic pain is still a major challenge to us. This article provides an overview of recent research on the role of NF-κ B in neuropathic pain.
