国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2012年
1期
58-60
,共3页
HMGB1%高迁移率族蛋白-1%脓毒症%炎症反应
HMGB1%高遷移率族蛋白-1%膿毒癥%炎癥反應
HMGB1%고천이솔족단백-1%농독증%염증반응
HMGB1%High mobility group box 1%Sepsis%Inflammatory
胞内HMGB1可以主动或被动释放到胞外,外源性HMGB1被认为是重要的晚期炎症因子,在炎症的发生发展中起重要作用.胞外HMGB1能与很多因子形成复合物,通过不同的受体通路影响转录因子NF-κB的活性,发挥不同的生物学效应.除发挥炎症因子的作用外,HMGB1在组织的修复和重建中的作用也不容小觑.另外,HMGB1预处理可以诱导产生免疫耐受,可能与脓毒症末期免疫功能低下有一定关系.
胞內HMGB1可以主動或被動釋放到胞外,外源性HMGB1被認為是重要的晚期炎癥因子,在炎癥的髮生髮展中起重要作用.胞外HMGB1能與很多因子形成複閤物,通過不同的受體通路影響轉錄因子NF-κB的活性,髮揮不同的生物學效應.除髮揮炎癥因子的作用外,HMGB1在組織的脩複和重建中的作用也不容小覷.另外,HMGB1預處理可以誘導產生免疫耐受,可能與膿毒癥末期免疫功能低下有一定關繫.
포내HMGB1가이주동혹피동석방도포외,외원성HMGB1피인위시중요적만기염증인자,재염증적발생발전중기중요작용.포외HMGB1능여흔다인자형성복합물,통과불동적수체통로영향전록인자NF-κB적활성,발휘불동적생물학효응.제발휘염증인자적작용외,HMGB1재조직적수복화중건중적작용야불용소처.령외,HMGB1예처리가이유도산생면역내수,가능여농독증말기면역공능저하유일정관계.
High mobility group box 1 ( HMGB1 ),released actively as well as passively following cytokine stimulation during cell death,has been implicated in several inflammatory disorders.It plays a vital role in the development of the inflammation.HMGB1 activates cells through cell surface receptors,and eventually regulates the activity of NF-κB.With the exception of its pro-inflammatory functions,recent findings indicate that HMGB1 also has restorative effects leading to tissue repair and regeneration.Furthermore,researches indicated that HMGB1 preconditioning in infection and inflammation could induce LPS tolerance which could be associated with sepsis-induced immunosuppression.
