中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2010年
12期
1083-1085
,共3页
张泮民%张永东%薛闽%王树宁
張泮民%張永東%薛閩%王樹寧
장반민%장영동%설민%왕수저
抑郁症%细胞因子%舍曲林%文拉法辛
抑鬱癥%細胞因子%捨麯林%文拉法辛
억욱증%세포인자%사곡림%문랍법신
Depression%Cytokine%Sertraline%Venlafaxin
目的 探讨首发抑郁症患者的细胞因子水平变化以及比较不同种类的抗抑郁剂舍曲林与文拉法辛对患者血清细胞因子水平的影响.方法 分别测定80例首发抑郁症患者的血清IL-2、IL-6、TNF-α、IL-10水平,并与40例健康对照者进行比较;80例首发抑郁症患者依抽签法分为人数相等的2组,分别经舍曲林、文拉法辛治疗6周后进行疗效评估,对舍曲林、文拉法辛治疗敏感的患者进行IL-2、IL-6、TNF-α、IL-10水平测定,并进行统计分析.结果 首发抑郁症患者的血清IL-2、IL-6、TNF-α细胞因子水平[(6.79±2.89)pg/ml,(10.12±4.52)pg/ml,(14.81±4.38)pg/ml]显著高于健康对照组[(4.06±2.05)pg/ml,(6.04±1.79)pg/ml,(10.69±2.54)pg/ml];舍曲林、文拉法辛治疗后较治疗前IL-6水平有显著降低(P＜0.05),IL-2、TNF-α、IL-10差异无显著性(P＞0.05),而舍曲林、文拉法辛两种抗抑郁剂对细胞因子水平的影响差异无显著性(P＞0.05).结论 首发抑郁症患者存在细胞因子水平的改变,并可以通过舍曲林、文拉法辛的治疗来矫正,而舍曲林、文拉法辛可能对细胞因子有相同的免疫作用机制.
目的 探討首髮抑鬱癥患者的細胞因子水平變化以及比較不同種類的抗抑鬱劑捨麯林與文拉法辛對患者血清細胞因子水平的影響.方法 分彆測定80例首髮抑鬱癥患者的血清IL-2、IL-6、TNF-α、IL-10水平,併與40例健康對照者進行比較;80例首髮抑鬱癥患者依抽籤法分為人數相等的2組,分彆經捨麯林、文拉法辛治療6週後進行療效評估,對捨麯林、文拉法辛治療敏感的患者進行IL-2、IL-6、TNF-α、IL-10水平測定,併進行統計分析.結果 首髮抑鬱癥患者的血清IL-2、IL-6、TNF-α細胞因子水平[(6.79±2.89)pg/ml,(10.12±4.52)pg/ml,(14.81±4.38)pg/ml]顯著高于健康對照組[(4.06±2.05)pg/ml,(6.04±1.79)pg/ml,(10.69±2.54)pg/ml];捨麯林、文拉法辛治療後較治療前IL-6水平有顯著降低(P＜0.05),IL-2、TNF-α、IL-10差異無顯著性(P＞0.05),而捨麯林、文拉法辛兩種抗抑鬱劑對細胞因子水平的影響差異無顯著性(P＞0.05).結論 首髮抑鬱癥患者存在細胞因子水平的改變,併可以通過捨麯林、文拉法辛的治療來矯正,而捨麯林、文拉法辛可能對細胞因子有相同的免疫作用機製.
목적 탐토수발억욱증환자적세포인자수평변화이급비교불동충류적항억욱제사곡림여문랍법신대환자혈청세포인자수평적영향.방법 분별측정80례수발억욱증환자적혈청IL-2、IL-6、TNF-α、IL-10수평,병여40례건강대조자진행비교;80례수발억욱증환자의추첨법분위인수상등적2조,분별경사곡림、문랍법신치료6주후진행료효평고,대사곡림、문랍법신치료민감적환자진행IL-2、IL-6、TNF-α、IL-10수평측정,병진행통계분석.결과 수발억욱증환자적혈청IL-2、IL-6、TNF-α세포인자수평[(6.79±2.89)pg/ml,(10.12±4.52)pg/ml,(14.81±4.38)pg/ml]현저고우건강대조조[(4.06±2.05)pg/ml,(6.04±1.79)pg/ml,(10.69±2.54)pg/ml];사곡림、문랍법신치료후교치료전IL-6수평유현저강저(P＜0.05),IL-2、TNF-α、IL-10차이무현저성(P＞0.05),이사곡림、문랍법신량충항억욱제대세포인자수평적영향차이무현저성(P＞0.05).결론 수발억욱증환자존재세포인자수평적개변,병가이통과사곡림、문랍법신적치료래교정,이사곡림、문랍법신가능대세포인자유상동적면역작용궤제.
Objective To detect the levels of cytokines in first-episode depressant patients and the influence on the levels of cytokines after the treatment with sertraline and venlafaxin. Methods The levels of IL-2,IL-6,TNF-α and IL-10 were measured in 80 first-episode depressant patients and 40 healthy control subjects. 80first-episode depressant patients were divided into two groups which were treated by sertraline and venlafaxin respectively. The levels of the same items were measured after 6-week treatment with sertraline and venlafaxin. All data were statistically analyzed by SPSS. Results The levels of IL-2,IL-6,TNF-α in 80 first-episode depressant patients were significantly higher than that in control group( IL-2:(6.79 ± 2.89 )pg/ml vs (4.06 ± 2.05 )pg/ml;IL-6:(10.12 ±4.52)pg/ml vs (6.04 ± 1.79) pg/ml;TNF-α: ( 14.81 ±4.38) pg/ml vs ( 10.69±2.54) pg/ml)(P＜0.05). The level of IL-6 after treatment by sertraline and venlafaxin was lower than that before treatment.There were no significant difference of the levels of IL-2,TNF-α, IL-10 before and after treatment. No significant difference of the levels of cytokines were observed between the two groups which were treated by sertraline and venlafaxin. Conclusions There are some changes of the levels of cytokines in first-episode depressant patients, which might be corrected by the treatment with sertraline and venlafaxin. Sertraline and venlafaxin might have the same mechanisms to cytokines.
