CAJ | 학술논문

目的观察VAD方案联合沙利度胺和干扰素治疗多发性骨髓瘤的临床疗效和不良反应.方法 17例多发性骨髓瘤均采用VAD方案联合沙利度胺和干扰素治疗.沙利度胺的起始剂量为100mg/d,每周增加50 mg,直至剂量增加至200 mg/d.干扰素为300万单位/d,隔日1次.21 d为1周期.治疗2个周期后,根据血象、血清M蛋白、骨髓瘤细胞等指标来判断疗效,分为部分缓解、疾病稳定和疾病进展.结果部分缓解14例,疾病稳定2例,疾病进展1例,总有效率82.35%.主要不良反应有嗜睡、便秘、头晕、心动过缓和发热,但都能耐受.结论 VAD方案联合沙利度胺和干扰素治疗多发性骨髓瘤具有疗效高和耐受性好的优点,值得进一步的临床观察和推广.
목적 관찰VAD방안연합사리도알화간우소치료다발성골수류적림상료효화불량반응.방법 17례다발성골수류균채용VAD방안연합사리도알화간우소치료.사리도알적기시제량위100mg/d,매주증가50 mg,직지제량증가지200 mg/d.간우소위300만단위/d,격일1차.21 d위1주기.치료2개주기후,근거혈상、혈청M단백、골수류세포등지표래판단료효,분위부분완해、질병은정화질병진전.결과 부분완해14례,질병은정2례,질병진전1례,총유효솔82.35%.주요불량반응유기수、편비、두훈、심동과완화발열,단도능내수.결론 VAD방안연합사리도알화간우소치료다발성골수류구유료효고화내수성호적우점,치득진일보적림상관찰화추엄.
Objective To observe the efficacy and side effects of VAD regimen combined with thalidomide and interferon in treatment of multiple myeloma. Methods 17 patients with multiple myeloma were administrated with VAD regimen combined with thalidomide and interferon. The initial dose of thalidomide was 100mg/d, then increased 50 mg per week till 200 mg/d. The dose of interferon was 3 × 106 μ/d. The therapeutic effectiveness was classified into partial remission, stabilization and progression according to the change of peripheral blood counts, serum M protein, and bone marrow myeloma cells. Results The total efficiency rate was 82.35% ( 14 cases of partial remission). The main side effects were sleepiness, constipation, dizzy, bradycardia and fever, which all were tolerable. Conclusion The merits of VAD regimen combined with thalidomide and interferon in treatment of multiple myeloma are significant response rate, less side effects, good tolerance and safety. It is worthy for clinical investigation and widespread generalization.