CAJ | 학술논문

目的探讨放化疗所致口腔黏膜反应的有效防治措施.方法将我院2010年1月～2011年7月100例头颈部恶性肿瘤放化疗患者随机分为2组,试验组采用重组人粒细胞巨噬细胞集落刺激因子( rhGM - CSF)喷雾剂治疗放化疗所致口腔黏膜炎；对照组以安慰剂对照,辅以健康教育和整体护理,观察两组药物的疗效、疼痛缓解度和安全性.结果实验组的有效率为86％,对照组的有效率为32％,两组间差异有统计学意义(P＜0.05).试验组患者口腔疼痛缓解总有效率为76.0％,对照组为57.1％.实验组疼痛缓解显著优于对照组(P＜0.05).结论使用( rhGM - CSF)喷雾剂能明显减轻放化疗所致口腔黏膜炎,且安全性好,使用方便.
목적 탐토방화료소치구강점막반응적유효방치조시.방법 장아원2010년1월～2011년7월100례두경부악성종류방화료환자수궤분위2조,시험조채용중조인립세포거서세포집락자격인자( rhGM - CSF)분무제치료방화료소치구강점막염；대조조이안위제대조,보이건강교육화정체호리,관찰량조약물적료효、동통완해도화안전성.결과 실험조적유효솔위86％,대조조적유효솔위32％,량조간차이유통계학의의(P＜0.05).시험조환자구강동통완해총유효솔위76.0％,대조조위57.1％.실험조동통완해현저우우대조조(P＜0.05).결론 사용( rhGM - CSF)분무제능명현감경방화료소치구강점막염,차안전성호,사용방편.
Objective To explore an effective preventive measures for the oral mucosa reaction caused by chemo - radiotherapy.Methods A total of 100 cases of patients with head and neck malignant tumor undergone radiation and chemotherapy were randomly divided into two groups.The test group was treated with human recombinant granulocyte macrophage colony stimulating factor ( rhGM - CSF),and the control group was treated with placebo,accompanied by health education and holistic nursing care.Effectivity,pain relief and safety of rhGM - CSF in treatment of oral mucosal inflammation were evaluated between two groups.Results Total effective rate was noted in 86％ patients in test group and 32％ patients in control group respectively.The difference between the two groups was significant ( P ＜0.05).Pain relief was noted in 76.0％ patients in test group and 57.1％ patients in control group respectively.The difference between two groups was significant ( P =0.047 ).Conclusions rhGM - CSF was an effective preventive measure for treatment of oral mucosal inflammation caused by radiation and chemotherapy with good safety and convenient use.