CAJ | 학술논문

目的检测先天性肾积水患儿肾表皮生长因子(EGF)及转化生长因子β1(TGF-β1)蛋白表达的改变及其临床意义。方法应用免疫组化方法对15例患肾，6例正常肾进行染色观察。结果患肾EGF蛋白的表达减少，仅2例患肾的极少数远曲小管细胞胞浆有EGF蛋白的弱阳性表达。TGF-β1蛋白的表达增高，大部分近曲小管、少数肾小球上皮细胞、系膜细胞和极少数的远曲小管可见TGF-β1蛋白的强阳性表达。结论EGF、TGF-β1蛋白表达的改变可能和先天性肾积水患肾积水程度、患肾萎缩及间质纤维化有关。
목적검측선천성신적수환인신표피생장인자(EGF)급전화생장인자β1(TGF-β1)단백표체적개변급기림상의의。방법응용면역조화방법대15례환신，6례정상신진행염색관찰。결과환신EGF단백적표체감소，부2례환신적겁소수원곡소관세포포장유EGF단백적약양성표체。TGF-β1단백적표체증고，대부분근곡소관、소수신소구상피세포、계막세포화겁소수적원곡소관가견TGF-β1단백적강양성표체。결론EGF、TGF-β1단백표체적개변가능화선천성신적수환신적수정도、환신위축급간질섬유화유관。
Objective To evaluate the expression of EGF and TGF-β1 in congenital hydronephro sis. Methods The expression of EGF and TGF-β1 protein was determined in 15 renal specimens with hydronephrosis and 6 normal control specimens by immunohistochemisty. Results The expression of EGF protein was obviously reduced; there was mild positive expression of EGF protein in a few tubular cells in 2cases. The expression of TGF-β1 significantly increased and it was mainly localized in proximal tubular cells.Conclusions The abnormal expression of EGF and TGF-β1 in congenital hydronephrosis might related to the degree of hydronephrosis, renal atrophy and interstitial fibrosis.