CAJ | 학술논문

目的观察培美曲塞联合奥沙利铂治疗晚期食管癌的疗效和毒副反应.方法将66例晚期食管癌患者随机分为两组.治疗组给予培美曲塞500 mg/m2静滴,第1天;奥沙利铂120 mg/m2静滴,第1天,21 d为一周期.对照组给予5-氟脲嘧啶 500 mg/m2静滴,第1～5天;亚叶酸钙0.2 g静滴,第1～5天;顺铂80 mg/m2静滴,分3天,21 d为一周期.结果治疗组总缓解率为68.8%,对照组总缓解率为44.1%,两组比较有统计学意义(P＝0.044).治疗组白细胞减少的发生率低于对照组,但差异无统计学意义(P＞0.05);治疗组恶心、呕吐和腹泻发生率显著低于对照组(P均＜0.05),神经毒性的发生率显著高于对照组(P＜0.05或＜0.01).结论奥沙利铂联合培美曲塞治疗晚期食管癌安全、有效率高,毒性反应可以耐受.
목적 관찰배미곡새연합오사리박치료만기식관암적료효화독부반응.방법 장66례만기식관암환자수궤분위량조.치료조급여배미곡새500 mg/m2정적,제1천;오사리박120 mg/m2정적,제1천,21 d위일주기.대조조급여5-불뇨밀정 500 mg/m2정적,제1～5천;아협산개0.2 g정적,제1～5천;순박80 mg/m2정적,분3천,21 d위일주기.결과 치료조총완해솔위68.8%,대조조총완해솔위44.1%,량조비교유통계학의의(P＝0.044).치료조백세포감소적발생솔저우대조조,단차이무통계학의의(P＞0.05);치료조악심、구토화복사발생솔현저저우대조조(P균＜0.05),신경독성적발생솔현저고우대조조(P＜0.05혹＜0.01).결론 오사리박연합배미곡새치료만기식관암안전、유효솔고,독성반응가이내수.
Objective To evaluate the efficacy and the side effects of the regimen of pemetrexed combined with oxaliplatin in the treatment of advanced esophageal cancer. Methods Sixty-six patients with advanced esophageal cancer were enrolled and randomly divided into treatment group and control group. Treatment group:pemerexed 500mg/m2, d1;oxaliplatin 120 mg/m2, d1; with 21 days one cycle.Control group:5-Fu 500mg/m2, d1-5; CF 0.2, d1-5; DDP 80mg/m2, divided into 3 days; with 21 days one cycle. Results The CR rate of treatment group was 6.3% and RR was 68.8%, while 2.9% and 44.1% respectively in control group. Compared with control group, the CR rate of treatment group had no significant difference(P＞0.05); while RR had significant difference(P＝0.044). Compared with control group, the treatment group's incidence of leukopenia(P＞0.05), nausea and vomitting (P＝0.024)and diarrhea(P＝0.032)were lower, while the incidence of neuropathy(P＝0.000) was higher. Conclusions It is safe and effective to treat patients with advanced esophageal cancer with pemetrexed and oxaliplatin