有机化学
有機化學
유궤화학
CHINESE JOURNAL OF ORGANIC CHEMISTRY
2009年
7期
1068-1081
,共14页
李运波%唐凤翔%孟春%郭养浩
李運波%唐鳳翔%孟春%郭養浩
리운파%당봉상%맹춘%곽양호
3-哌啶甲酸%3-哌啶甲酸衍生物%药物中间体
3-哌啶甲痠%3-哌啶甲痠衍生物%藥物中間體
3-고정갑산%3-고정갑산연생물%약물중간체
nipecotic acid%nipecotic acid derivative%pharmaceutical intermediate
3-哌啶甲酸及其衍生物是重要的药物中间体,具有很高的生物活性.综述了3-哌啶甲酸及其羧基酯化、不饱和、不同位置取代与多取代衍生物的合成方法,并对3-哌啶甲酸及其衍生物在合成γ-氨基丁酸(GABA)摄入抑制剂、抗肿瘤药、生长激素促分泌素、消炎药物、心血管药物、促智药物、抗流感病毒、骨疾病等药物中的应用进行了概述.
3-哌啶甲痠及其衍生物是重要的藥物中間體,具有很高的生物活性.綜述瞭3-哌啶甲痠及其羧基酯化、不飽和、不同位置取代與多取代衍生物的閤成方法,併對3-哌啶甲痠及其衍生物在閤成γ-氨基丁痠(GABA)攝入抑製劑、抗腫瘤藥、生長激素促分泌素、消炎藥物、心血管藥物、促智藥物、抗流感病毒、骨疾病等藥物中的應用進行瞭概述.
3-고정갑산급기연생물시중요적약물중간체,구유흔고적생물활성.종술료3-고정갑산급기최기지화、불포화、불동위치취대여다취대연생물적합성방법,병대3-고정갑산급기연생물재합성γ-안기정산(GABA)섭입억제제、항종류약、생장격소촉분비소、소염약물、심혈관약물、촉지약물、항류감병독、골질병등약물중적응용진행료개술.
Nipecotic acid and its derivatives, which have high bioactivity, are significant pharmaceutical intermediates. In this review, the synthetic methods of nipecotic acid and its derivatives are summarized.The application of nipecotic acid and its derivatives to synthesizing drugs for γ-aminobutyric acid (GABA) uptake inhibition, cancer chemotherapy, growth hormone secretion, anti-inflammation, cardiovascular disease, Alzheimer's disease, nootropics, anti-flu virus and bone disease is presented as well.
