CAJ | 학술논문

目的了解重组生长激素(rh-GH)对大面积烧伤病人静息能量消耗(REE)、呼吸商(RQ)及蛋白合成的影响。方法选择24小时入院重度烧伤而无合并伤的38例病人，治疗组24例，对照组14例。按代谢车实测值给予能量，治疗组伤后一周给予rh-GH0.2IU/(kg*d)(长春金塞药业生产)，于晨6时肌肉注射。选择用药第3、5、7天，用药后2～3小时、5～6小时及8小时后实测REE、RQ，于治疗前1天及治疗后1、2、3周第一天晨抽静脉血，测血清白蛋白、总蛋白、转铁蛋白、前白蛋白。结果rh-GH治疗组REE明显低于对照组，RQ明显增高，尤其在rh-GH药效高峰期更为显著(P0.05～0.01)。rh-GH治疗后蛋白浓度明显高于对照组，在治疗后两周较为显著(P0.05～0.01)，而对照组间却无明显变化。结论rh-GH有助于遏止机体高分解代谢，促进蛋白合成的作用。
목적료해중조생장격소(rh-GH)대대면적소상병인정식능량소모(REE)、호흡상(RQ)급단백합성적영향。방법선택24소시입원중도소상이무합병상적38례병인，치료조24례，대조조14례。안대사차실측치급여능량，치료조상후일주급여rh-GH0.2IU/(kg*d)(장춘금새약업생산)，우신6시기육주사。선택용약제3、5、7천，용약후2～3소시、5～6소시급8소시후실측REE、RQ，우치료전1천급치료후1、2、3주제일천신추정맥혈，측혈청백단백、총단백、전철단백、전백단백。결과rh-GH치료조REE명현저우대조조，RQ명현증고，우기재rh-GH약효고봉기경위현저(P0.05～0.01)。rh-GH치료후단백농도명현고우대조조，재치료후량주교위현저(P0.05～0.01)，이대조조간각무명현변화。결론rh-GH유조우알지궤체고분해대사，촉진단백합성적작용。
Objective To realize that the effect on REE,RQ.And proteinanabolism in severely burned patients treated with rh-GH. Methods 38 cases of severely burned patient S without combined injury and admission within 24h after.Burn were divided into GH group.(n=24) and Control group.(n=14).Energy supplied according to the actual value of CCM metabolism car.In GH group,GH was given intramuscularly at 6 oclock Am during 1 w after burn,REE and RQ of the patients were measured with CCM on 2-3h,5-6h and >8h three time points after receiving GH.Serum albumin,total protein,transferrin,prealbumin were measured for protein metabolisms I day before treatment and the 1st moriing of 1st,2nd,3rd,week after administration of GH. Results REE in patients received GH was apparently lower than control group,RQ improved greatly.The protein contents in GH group was higher than control group,especially two months after treatment. Conclusions rh-GH can depress high catabolism of the body,at the same time it increases.protein synthesis.