CAJ | 학술논문

目的　探讨冠心病(CHD)患者血清真胰岛素(TI)、胰岛素原(PI)水平，并分析这二者与其他CHD危险因子的关系。方法　对30例确诊CHD患者和30例正常人采用高度特异性的ELISA法分别检测空腹血清TI、PI和以RIA法检测空腹血清免疫活性胰岛素(IRI)水平；同时检测这二组对象的空腹和餐后2小时血糖、血脂以及血压水平。结果　CHD组IRI、TI、PI水平均高于对照组(P＜0.05)，而胰岛素敏感指数(ISI)则低于对照组(P＜0.05)。CHD组中TI、PI与年龄、BMI、血糖和血脂均有独立的相关关系。结论　CHD患者有高胰岛素血症和胰岛素抵抗状态，TI、PI分别与血糖、血脂等CHD危险因子呈群聚关系。
목적　탐토관심병(CHD)환자혈청진이도소(TI)、이도소원(PI)수평，병분석저이자여기타CHD위험인자적관계。방법　대30례학진CHD환자화30례정상인채용고도특이성적ELISA법분별검측공복혈청TI、PI화이RIA법검측공복혈청면역활성이도소(IRI)수평；동시검측저이조대상적공복화찬후2소시혈당、혈지이급혈압수평。결과　CHD조IRI、TI、PI수평균고우대조조(P＜0.05)，이이도소민감지수(ISI)칙저우대조조(P＜0.05)。CHD조중TI、PI여년령、BMI、혈당화혈지균유독립적상관관계。결론　CHD환자유고이도소혈증화이도소저항상태，TI、PI분별여혈당、혈지등CHD위험인자정군취관계。
Objective　To determine serum true insulin (TI) and proinsulin (PI) levels in patients with coronary heart disease (CHD), and to explore the relationships of them to other cardiovascular risk factors. Methods　Highly specific ELISA assays for TI and PI and RIA for immunoreactive insulin (IRI) were used. The fasting serum IRI, TI, PI levels in 30 nondiabetic patients with CHD and 30 healthy, age-matched control subjects were investigated. And the fasting and 2h postprandial plasma glucose, serum lipids and blood pressure were also determined in each individuals. Results　The levels of serum IRI, TI and PI were significantly higher in patients with CHD than those in controls (P＜0.05), while the value of insulin sensitivity index (ISI) was lower in patients with CHD than in controls (P＜0.05). There were significant independent correlations between TI, PI and age, BMI, plasma glucose, serum lipids. Conclusion Nondiabetic patients with CHD have hyperinsulinemia and insulin resistance and there is an independent association between proinsulin and dyslipidemia.