CAJ | 학술논문

目的Monte Carlo仿真是研究光在组织中传播规律的有效方法.该文在组织漫反射光MonteCarlo仿真的基础上,提出了一种新的荧光光子迁移方法,并由此实现了对组织自体荧光的仿真.方法根据荧光光子产生和传播的原理,模型中对激发光和荧光光子采用了加权的光子模型.激发光子和荧光光子的运动彼此独立,每产生一个荧光光子,将跟踪其运动直至终止,然后继续跟踪激发光子的运动.所有统计量采用改进的Monte Carlo仿真软件计算.主动脉中层组织模型的仿真结果与文献结果进行了比较.结果仿真结果表明,对于主动脉组织模型,在520 nm和600nm处有两个荧光峰,这与文献的结果是完全一致的.荧光强度与荧光逃逸位置的关系表明,随着逃逸半径的增大,荧光强度迅速减小,这一结果对于激发和采集光纤的设计具有指导意义.结论该文所述组织荧光仿真方法直接从荧光光子产生及运动的原理出发,简单明了,计算简单,易于实现.由于MonteCarlo方法是基于大量事件的统计规律之上的,因此进行一次仿真所需的时间是制约其应用的一大因素,其算法有待于作更进一步的优化.
목적Monte Carlo방진시연구광재조직중전파규률적유효방법.해문재조직만반사광MonteCarlo방진적기출상,제출료일충신적형광광자천이방법,병유차실현료대조직자체형광적방진.방법근거형광광자산생화전파적원리,모형중대격발광화형광광자채용료가권적광자모형.격발광자화형광광자적운동피차독립,매산생일개형광광자,장근종기운동직지종지,연후계속근종격발광자적운동.소유통계량채용개진적Monte Carlo방진연건계산.주동맥중층조직모형적방진결과여문헌결과진행료비교.결과방진결과표명,대우주동맥조직모형,재520 nm화600nm처유량개형광봉,저여문헌적결과시완전일치적.형광강도여형광도일위치적관계표명,수착도일반경적증대,형광강도신속감소,저일결과대우격발화채집광섬적설계구유지도의의.결론해문소술조직형광방진방법직접종형광광자산생급운동적원리출발,간단명료,계산간단,역우실현.유우MonteCarlo방법시기우대량사건적통계규률지상적,인차진행일차방진소수적시간시제약기응용적일대인소,기산법유대우작경진일보적우화.
Objective:The excitation light and reemitted fluorescence can be influenced by tissue properties,such as absorption, scattering and other factor. So in order to diagnose tissue with fluorescence, it is important to research into the regulation of fluorescence generating and propagating in theory. Monte Carlo simulation is an efficient method in studying light propagating in human tissue. In this paper, a new photon migration approach for modeling fluorescence in tissue is described in detail based on diffusive reflectance light Monte Carlo model. Methods:In this model, weighted photon model for excitation photon and reemitted fluorescence was utilized. The movement of excitation photon and emitted fluorescence photon is independent of each other. Once a fluorescence packet is generated, it will be traced until termination. And then go on to trace the movement of excitation photon packet. All the statistical values were calculated with modified Monte Carlo Simulation soft ware developed by author. The simulation results of human aortic intima tissue optical model were compared with literature. Results: For human aortic intima model, there are two main fluorescence peaks at emission wavelength 520 nm and 600 nm which is exactly agreed with the results of literature. The relationship between relative fluorescence intensity and escaped radius position indicates that the fluorescence intensity decreases greatly with radius increasing centered on the excitation light source. The result is valuable for the design of exciation and collection fibers in practice. Conclusions:The method presented in this paper is directly induced from the principle of fluorescence generation and movement, and is perspicuous and easily avaiable.For Monte Carlo simulation is based on a large number of random events and statistic regulation,it is time consuming. With the rapid progrss of the computer science and technology, this methodology will play a more important role in the theory and application research of light propagating through complex mediun.