CAJ | 학술논문

目的：探讨粘附分子上皮型钙粘连素（E-cadherin）和CD44v6在人肝细胞癌（HCC）中表达的意义。方法：用免疫组化法检测66例人HCC组织中E-cadherin和CD44v6的表达。结果：人HCC中E-cadherin和CD44v6表达的阳性率分别为42.4%和39.4%，且E-cadherin表达与HCC侵袭转移倾向呈负相关（P<0.01），与患者5年生存率呈正相关（P<0.01）；而CD44v6表达与HCC侵袭转移倾向呈正相关（P<0.01），与患者5年生存率呈负相关（P<0.05）。结论：E-cadherin和CD44v6均与肝癌侵袭转移倾向有关，检测E-cadherin和CD44v6的表达可以作为判断肝癌预后的参考指标。
목적：탐토점부분자상피형개점련소（E-cadherin）화CD44v6재인간세포암（HCC）중표체적의의。방법：용면역조화법검측66례인HCC조직중E-cadherin화CD44v6적표체。결과：인HCC중E-cadherin화CD44v6표체적양성솔분별위42.4%화39.4%，차E-cadherin표체여HCC침습전이경향정부상관（P<0.01），여환자5년생존솔정정상관（P<0.01）；이CD44v6표체여HCC침습전이경향정정상관（P<0.01），여환자5년생존솔정부상관（P<0.05）。결론：E-cadherin화CD44v6균여간암침습전이경향유관，검측E-cadherin화CD44v6적표체가이작위판단간암예후적삼고지표。
Objective: To investigate the significance of E-cadherin andCD44v6 expression in human hepatocellular carcinoma(HCC). Methods: Immunohistochemical method was used to detect E-cadherin and CD44v6 expression in 66 cases of HCC. Results: The positive rates of E-cadherin and CD44v6 expression in human HCC were 42.4％（28/66）and 39.4%（26/66）, respectively. There was a negative correlation between E-cadherin expression and invasive, metastatic potential of HCC(P<0.01) and a positive correlation between the CD44v6 expression and invasive, metastatic potential of HCC (P<0.01). Moreover, the survival of patients for 5 years in E-cadherin positive expression group was higher than that in E-cadherin negative expression group（P<0.01）, and the survival of patients for 5 years in CD44v6 positive expression group was lower than that in CD44v6 negative expression group（P<0.05）. Conclusion: These data show a correlation between E-cadherin and CD44v6 expression and invasive and metastatic potential in HCC. E-cadherin and CD44v6 expression may be 2 prognostic indicators in HCC.