CAJ | 학술논문

目的从血液流变学角度探讨复方丹参对精神分裂症的辅助治病作用。方法对符合CCMD-2-R精神分裂症诊断标准的120例患者进行分组治疗，研究组30例以抗精神病药加复方丹参，对照组90例单以抗精神病药治疗，观察4周，分别于治疗前和4周后检则血液流变学12项指标和简明精神病量表(BPRS)总分。结果研究组治疗4周后的全血粘度(300s-1和1.0s-1、低切还原粘度、RBC刚性指数、RBC聚集指数和纤维蛋白原都显著低于治疗前且都显著低于对照组(P<0.05～0.01)，脑血流量则显著高于治疗前(P<0.05)；而对照组除全血粘度有显著改善外其它指标在治疗前后无显著性差异(P>0.05)。研究组治疗4周后的BPRS减分率显著高于对照组(P<0.01)。结论复方丹参对精神分裂症有辅助治疗作用，能改善精神分裂症的高粘滞血症和提高BPRS减分率。
목적종혈액류변학각도탐토복방단삼대정신분렬증적보조치병작용。방법대부합CCMD-2-R정신분렬증진단표준적120례환자진행분조치료，연구조30례이항정신병약가복방단삼，대조조90례단이항정신병약치료，관찰4주，분별우치료전화4주후검칙혈액류변학12항지표화간명정신병량표(BPRS)총분。결과연구조치료4주후적전혈점도(300s-1화1.0s-1、저절환원점도、RBC강성지수、RBC취집지수화섬유단백원도현저저우치료전차도현저저우대조조(P<0.05～0.01)，뇌혈류량칙현저고우치료전(P<0.05)；이대조조제전혈점도유현저개선외기타지표재치료전후무현저성차이(P>0.05)。연구조치료4주후적BPRS감분솔현저고우대조조(P<0.01)。결론복방단삼대정신분렬증유보조치료작용，능개선정신분렬증적고점체혈증화제고BPRS감분솔。
Objective To explore the adjunct effects of Radix Salviae Miltorrhzae Compsita(RSMC) in the treatment of schizophrenia on hemorheology. Method 120 cases with the diagnosis of schizophrenia according to CCMD-2-R were assigned into the tested(n=30) and control group(n=90). Patients in the tested group were treated with antipsychotic drugs and RSMC 3#, orally, tid; while subjects in the control group only with antipsychotic drugs, for the course of 4 weeks. The two group patients were respectively cheched up 12 hemorheological indices and Brief Psychiatric Rating Scale(BPRS) before and after 4 weeks of treatment. Results The whole blood viscosity (300s-1 and 1.0s-1), low shear reduction viscosity, red blood cell(RBC) stiffness index, RBC aggregation index and fibrinogen in the tested group after 4 weeks of treatment were significantly lower than that before treatment as well as in the control group (P<0.05 or 0.01); while cerebral blood flow showed significantly higher than that before treatment (P<0.05). The control group showed no sighificant difference (p>0.05) between before and after 4 weeks of treatment except the whole blood viscosity improvement (P<0.01). BPRS score reduced rate in the tested group after 4 weeks of treatment showed sighificantly higher than in the control. Conclusion There are adjunct effects of RSMC in the treatment of schizophrenia. RSMC can improve the hypervis-semia and increase BPRS score reduced rate in schizophrenia.