CAJ | 학술논문

目的：了解急性脑梗死病人血浆内皮素(ET)的变化以及尼莫地平对它的影响。方法：66例急性脑梗死(ACI)病人根据入院时的血压情况随机分为2组：高血压脑梗死组35例［男性20例，女性15例，年龄(65±s11) a］和单纯脑梗死组31例［男性17例，女性14例，年龄(62±10)a］。采用放射免疫法测定ET浓度，并与27例健康对照者比较，其中42例ACI病人（2组分别为25例和17例）接受尼莫地平4 mg，iv, gtt,qd，2 wk后复测ET。结果：2组脑梗死病人血浆ET浓度分别为(144±42) ng*L-1和(72±35) ng*L-1。尼莫地平治疗后，分别为(94±55) ng*L-1和(60±37) ng*L-1，但仍高于对照组（P<0.01)。结论：ET与ACI有着密切联系；尼莫地平静滴在明显改善神经症状的同时可明显降低ET。
목적：료해급성뇌경사병인혈장내피소(ET)적변화이급니막지평대타적영향。방법：66례급성뇌경사(ACI)병인근거입원시적혈압정황수궤분위2조：고혈압뇌경사조35례［남성20례，녀성15례，년령(65±s11) a］화단순뇌경사조31례［남성17례，녀성14례，년령(62±10)a］。채용방사면역법측정ET농도，병여27례건강대조자비교，기중42례ACI병인（2조분별위25례화17례）접수니막지평4 mg，iv, gtt,qd，2 wk후복측ET。결과：2조뇌경사병인혈장ET농도분별위(144±42) ng*L-1화(72±35) ng*L-1。니막지평치료후，분별위(94±55) ng*L-1화(60±37) ng*L-1，단잉고우대조조（P<0.01)。결론：ET여ACI유착밀절련계；니막지평정적재명현개선신경증상적동시가명현강저ET。
AIM: To explore the role of plasma endothelin (ET) in patients with acute cerebral infarction (ACI) and its change after nimodipine treatment.METHODS:Sixty-six patients with ACI were randomly divided into 2 groups according to blood pressure:hypertension ACI group 35 patients［M 20,F 15;age (65±　s　11) a］ and pure ACI group 31 patients［M 17,F 14; age (62±10) a］.Plasma ET was measured by radioimmunoassay and compared with 27 healthy individuals.Among them,42 patients（hypertension ACI group 25 patients，pure ACI group 17 patients） with ACI were given nimodipine 4 mg, iv,gtt, qd, for 2 wk and measured ET again.　RESULTS:Plasma ET in 2 groups were (144±42) ng*L-1 and (72±35) ng*L-1 respectively, and that were (94±55) ng*L-1 and (60±37) ng*L-1 respectively after treatment with nimodipine, but was still higher than that in healthy individuals (P<0.01).　CONCLUSION: The level of plasma ET was associated with blood pressure and the severity of disease. ET is closely related with ACI. Nimodipine reduces the plasma ET while nerve function default degree is effectively improved.