CAJ | 학술논문

目的探讨脑血管病患者脂蛋白(a)〔Lp(a)〕和其它脂类水平与脑血管病的关系。方法采用试剂盒检测55例脑出血，57例脑梗塞患者Lp(a)水平及胆固醇(Ch)、甘油三酯(TG)、高密度脂蛋白(HDL)、载脂蛋白A-I(Apo A-I)和载脂蛋白B(Apo B)，并与85例健康对照者作比较。结果脑梗塞组Lp(a)、Apo B及TG升高，HDL及Apo A-I下降；脑出血组Lp(a)、Apo B及TG上升，Ch及HDL下降明显。脑梗塞组Lp(a)与TG呈显著正相关，而脑出血组Lp(a)与Ch呈显著负相关。脑梗塞组Lp(a)、TG异常检出率分别高达59.65%、52.63%，脑出血组HDL异常检出率高达50.91%。结论 Lp(a)和其它脂类代谢异常是脑血管病患者最常见和重要的致病因素之一。
목적탐토뇌혈관병환자지단백(a)〔Lp(a)〕화기타지류수평여뇌혈관병적관계。방법채용시제합검측55례뇌출혈，57례뇌경새환자Lp(a)수평급담고순(Ch)、감유삼지(TG)、고밀도지단백(HDL)、재지단백A-I(Apo A-I)화재지단백B(Apo B)，병여85례건강대조자작비교。결과뇌경새조Lp(a)、Apo B급TG승고，HDL급Apo A-I하강；뇌출혈조Lp(a)、Apo B급TG상승，Ch급HDL하강명현。뇌경새조Lp(a)여TG정현저정상관，이뇌출혈조Lp(a)여Ch정현저부상관。뇌경새조Lp(a)、TG이상검출솔분별고체59.65%、52.63%，뇌출혈조HDL이상검출솔고체50.91%。결론 Lp(a)화기타지류대사이상시뇌혈관병환자최상견화중요적치병인소지일。
Objective To study the relationship between the changes of lipoprotein(a), other lipids and cerebrovascular diseases. Methods The serum levels of lipoprotein(a)〔Lp(a)〕apolipoprotein A-I (Apo A-I),apolipoprotein B(Apo B),cholesterol (Ch), triglyceride (TG) and high density lipoprotein cholesterol (HDL) were determined in 55 patients with cerebral infarction, 57 patients with cerebral hemorrhage and in 85 healthy controls by reagent kit. Results It was found that patients with cerebral infarction had significantly higher levels of Lp(a), Aop B and TG, and lower level of HDL.Patients with cerebral hemorrhage had significantly higher levels of Lp(a), Apo B, TG, and lower level of Ch than controls did. There was a significantly positive correlation between Lp(a) and TG in patients with cerebral infarction,while a significantly negative correlation between Lp(a) and Ch in patients with cerebral hemorrhage. The detective rates of abnormal Lp(a) and TG in cerebral infarction were as high as 59.65% and 52.63% respectively. The detective rate of abnormal HDL in cerebral hemorrhage was as high as 50.91%. Conclusion It is suggested that the abnormal Lp(a) and other lipids are one of the most common and important risk factors for cerebrovascular diseases.