CAJ | 학술논문

目的探讨慢性粒细胞白血病(CML)患者血清乳酸脱氢酶(LDH)的变化及LDH与其他预后因素的关系。方法检测68例CML患者血清LDH及其同工酶,分析LDH与患者临床特征、外周血、骨髓细胞学和bcr-abl基因表达(P210)的关系。结果 CML患者的血清LDH及其同工酶均有不同程度的升高,并与血白细胞、P210、骨髓增生程度、脾肿大有关,但与血红蛋白、血小板、肝肿大、年龄和性别无关。结论检测血清LDH有助于CML的诊断和预后评估。
목적탐토만성립세포백혈병(CML)환자혈청유산탈경매(LDH)적변화급LDH여기타예후인소적관계。방법검측68례CML환자혈청LDH급기동공매,분석LDH여환자림상특정、외주혈、골수세포학화bcr-abl기인표체(P210)적관계。결과 CML환자적혈청LDH급기동공매균유불동정도적승고,병여혈백세포、P210、골수증생정도、비종대유관,단여혈홍단백、혈소판、간종대、년령화성별무관。결론검측혈청LDH유조우CML적진단화예후평고。
Objective To investigate the change of serum lactate dehydrogenase(LDH) and its relationship with other prognostic factors in patients with chronic myelogenous leukemia(CML). Methods LDH and its isoenzyme were measured in 68 cases of CML. The relationship between the enzyme level and clinical features, peripheral blood leukocyte count, bone marrow cellularity as well as P210 positive cell percentage of peripheral blood mononuclear cells(P210%) were analysed. Results The average values of LDH and its isoenzyme increased in CML patients, which were significantly associated with peripheral blood leukocyte count, bone marrow cellularity, spleen size and P210%. No significant association was found between the enzyme and Hb, Plt, liver size, age as well as sex. Conclusion Analysis of the LDH mye be helpful in the diagnosis and prognosis of CML.