CAJ | 학술논문

比较了抗癌结构类似物吗丙嗪和雷佐生对红细胞膜钙调蛋白(CaM)活性的影响.观察兔红细胞膜Ca2+，Mg2+-ATP酶(CaM的靶酶)活性反映膜CaM激活ATP酶的活性.结果显示吗丙嗪(0.1～1mmol.L-1)浓度依赖性抑制CaM激活ATP酶活性(下降11%～32%).雷佐生在高浓度(0.5mmol.L-1)仍未显示抑制CaM激活ATP酶活性的作用.吗丙嗪在低浓度(0.02～0.1mmol.L-1)能增加N-乙酰神经氨酸(0.2mmol.L-1)抑制CaM激活ATP酶活性的作用.结果表明吗丙嗪对CaM活性的抑制作用强于雷佐生，因而可能在CaM介导的抑瘤途径的作用较雷佐生强,且其作用可能与神经氨酸(唾液酸)有关.
비교료항암결구유사물마병진화뢰좌생대홍세포막개조단백(CaM)활성적영향.관찰토홍세포막Ca2+，Mg2+-ATP매(CaM적파매)활성반영막CaM격활ATP매적활성.결과현시마병진(0.1～1mmol.L-1)농도의뢰성억제CaM격활ATP매활성(하강11%～32%).뢰좌생재고농도(0.5mmol.L-1)잉미현시억제CaM격활ATP매활성적작용.마병진재저농도(0.02～0.1mmol.L-1)능증가N-을선신경안산(0.2mmol.L-1)억제CaM격활ATP매활성적작용.결과표명마병진대CaM활성적억제작용강우뢰좌생，인이가능재CaM개도적억류도경적작용교뢰좌생강,차기작용가능여신경안산(타액산)유관.
To compare the effects of antitumor derivatives probimane andrazoxane on calmodulin(CaM) in rabbit erythrocytes by observing CaM activated Ca2+,Mg2+-ATPase activity of rabbit erythrocyte membranes. It was showed that probimane (0.1－1.0 mmol.L-1) inhibited cell CaM activated Ca2+,Mg2+-ATPase activity (decreasing 11%－32%) in a dose-dependent manner. Razoxane at a concentration of 0.5 mmol.L-1 did not inhibit CaM activated Ca2+,Mg2+-ATPase activity. Probimane at low concentrations (0.02－0.1 mmol.L-1) enhanced the inhibitory effect of N-acetylneuraminic acid on CaM activated Ca2+,Mg2+-ATPase activity. The results manifest that probimane may be more potent to CaM pathways of tumor than razoxane does and its effect might be correlated with neuraminic acids(sialic acids).