CAJ | 학술논문

目的：比较钩藤中提取的异钩藤碱、钩藤碱、钩藤总碱及非生物碱部分的降压作用。方法：大鼠麻醉后经颈总动脉插管记录外周血压和经股静脉微量输注实验用药。结果：实验表明钩藤中4种成分的降压强度为异钩藤碱(42．0％)>钩藤碱(32．1％)>钩藤总碱(21.3％)>钩藤非生物碱(12．4％)。结论：提示钩藤中主要降压成分为异钩藤碱和钩藤碱。
목적：비교구등중제취적이구등감、구등감、구등총감급비생물감부분적강압작용。방법：대서마취후경경총동맥삽관기록외주혈압화경고정맥미량수주실험용약。결과：실험표명구등중4충성분적강압강도위이구등감(42．0％)>구등감(32．1％)>구등총감(21.3％)>구등비생물감(12．4％)。결론：제시구등중주요강압성분위이구등감화구등감。
Hypotensive effects of rhynchophylline, isorhynchophylline, total alkaloid and non-alka-loid fraction isolated from Uncaria rhynchophylla (Miq.) Jacks. were compared. Change in peripheralblood pressure was recorded by inserting a catheter into the right common carotid artery of anaethetizedrat, while each of the four hypotensive constituents was injected individually into the femoral vein by a mi-croinfusion pump. Results of the findings showed that the four constituents in U. rhynchophylla displayeddifferent hypotensive potency in the order of isorhynchophylline [lowering of mean arterial pressure(MAP) by 42.0%] > rhynchophylline (lowering of MAP by 32.1%) > total alkaloid (lowering of MAPby 21.3%) > non-alkaloid fraction (lowering of MAP by 12.4%). It was concluded that isorhyn-chophylline and rhynchophylline were the main hypotensive constituents in U. rhynchophylla.